[ALCAM is a cell adhesion molecule expressed on mitogen-activated leukocytes and monocytes, fibroblasts, neurons, and tumor-derived cell lines but not on unactivated leukocytes. ALCAM is a ligand for CD6, a receptor expressed on T-cells involved in cell adhesion interactions between thymocytes and thymic epithelial cells. ALCAM/CD6 interactions may play a role in the binding of T- and B-cells to activated leukocytes. ALCAM has five Ig domains and its amino acid sequence has significant homology to chicken neural adhesion molecule BEN/SC-1/DM-GRASP. (from OMIM 601662 and NCI) ( NCI )]
UMLS (NCI) C0295967 - Amino Acid, Peptide, or Protein
- Carbohydrate
- Immunologic Factor
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