ANOVA

[Expressed in brain by human NOVA2 Gene, RNA-binding NOVA2 protein is recognized by the paraneoplastic syndrome antibody anti-Ri. NOVA1 and NOVA2 bind to similar RNA ligands with high affinity and may regulate RNA splicing. The NOVA2 KH3 domain interacts with single-stranded RNA; KH3 bound to stem loop RNA resembles a vise, with UCAC held between an invariant Gly-X-X-Gly motif and a variable loop. Tetranucleotide recognition is supported by an aliphatic alpha-helix/beta-sheet RNA-binding platform that mimics UG by making Watson-Crick-like hydrogen bonds with CA. (NCI) ( NCI )]

UMLS (NCI) C1367971

Neuro-Oncological Ventral Antigen 2
Neuro-Oncological Ventral Antigen 3
NOVA2
NOVA3