AGO Protein

[Encoded by human FBXW7 Gene, alpha and beta AGO Protein (F-Box Family), 707 and 627 amino acids respectively, differ in their N-termini and contain the putative functional F box and seven WD repeats. F-box proteins constitute one of four SCF subunits of the ubiquitin protein ligase complex, involved in phosphorylation-dependent ubiquitination. AGO protein binds to cyclin E, and probably targets it for ubiquitin-mediated degradation. AGO mutant cells have elevated levels of cyclin E without increased cyclin E mRNA levels. Homologue of Cdc4 (S. cerevisiae) and Archipelago (Drosophila), human AGO also has low similarity to Met30p (S. cerevisiae). Drosophila and human AGO are 78% identical. AGO may represent a mutational target in ovarian cancer. (from OMIM and NCI) ( NCI )]

UMLS (NCI) C0755295

Archipelago Homologue Protein
F-box and WD-40 domain protein 7
F-box protein FBW7
FBXW7
FBXW7 Protein