[The ABL protein is a constitutively active tyrosine kinase that may regulate signal transduction events in the cytoplasm and processes in the nucleus. It is repressed by SH3 domains and possibly by other regions. ABL-Interactor 2, encoded by the ABI-2 gene, is the substrate for ABL. This protein has an SH3 domain and interacts with the ABL. ABI-2 may function to coordinate the cytoplasmic and nuclear functions of the ABL. It modulates ABL transforming activity and functions as a tumor suppressor in mammalian cells. (From LocusLink, OMIM) ( NCI )]
UMLS (NCI) C0384027 - Amino Acid, Peptide, or Protein
- Biologically Active Substance
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