[An oral prodrug of 5-iododeoxyuridine (IUdR), an iodinated analogue of deoxyuridine and radiosensitizing agent. 5-Iodo-2-pyrimidinone-2-deoxyribose (IPdR) is efficiently converted to IUdR by a hepatic aldehyde oxidase. This results in increased IUdR plasma levels compared to oral IPdR and increased toxicity profile compared to intravenous administered IUdR. IUdR is incorporated into DNA during the S-phase of the cell cycle, thereby sensitizing cells to ionizing radiation by increasing DNA strand breaks. ( NCI )]
UMLS (NCI) C0088688 - Nucleic Acid, Nucleoside, or Nucleotide
- Pharmacologic Substance
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