I I- I0 I1 I2 I3 I4 I5 I6 I7 I8 I9 IA IB IC ID IE IF IG IH II IK IL IM IN IO IP IQ IR IS IT IU IV IX
3-Isoxazolecarboxylic Acid, 5-methyl-, 2-(phenylmethyl)hydrazide
[A hydralazine and monoamine oxidase (MAO) inhibitor with antidepressant activity. Isocarboxazid blocks the breakdown (oxidative deamination) of biogenic amines by inhibiting MAO, thereby increasing the concentrations of norepinephrine and 5-hydroxytrytamine (5-HT) at central aminergic receptors. These neurotransmitters are involved in sustaining mood and emotions. The down-regulation of central beta-adrenergic and serotonergic receptors by chronic inhibition of MAO may also contribute to the antidepressant effects seen by isocarboxazid. (NCI05) ( NCI )]
UMLS (NCI) C0022154- Organic Chemical
- Pharmacologic Substance
Relation/PAR: isoxazole
[CN602] MONOAMINE OXIDASE INHIBITOR ANTIDEPRESSANTS
[CN602] MONOAMINE OXIDASE INHIBITOR ANTIDEPRESSANTS
Relation/CHD: ISOCARBOXAZID 10 MG
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