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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
P P- P0 P1 P2 P3 P4 P5 P6 P7 P8 P9 PA PB PC PD PE PF PG PH PI PK PL PM PN PO PP PQ PR PS PT PU PV PW PX PY
PC PC- PC0 PC1 PC2 PC4 PC5 PCA PCB PCC PCD PCF PCH PCI PCL PCM PCN PCO PCP PCR PCS PCT PCV PCY

1-(p-Chlorophenyl)-5-isopropylbiguanide Hydrochloride

[The hydrochloride salt form of proguanil, a synthetic biguanide derivative of pyrimidine and an folate antagonist with antimalarial property. Upon hydrolysis, proguanil is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite. ( NCI )]
UMLS (NCI) C0546856
 
Organic Chemical
Pharmacologic Substance

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