[A benzothiazepine derivative and a calcium channel blocker with vasodilator, antihypertensive and cardiovascular properties. Diltiazem maleate inhibits the influx of calcium ions of coronary and peripheral vascular smooth muscle. This leads to a dilation of peripheral and coronary blood vessels, and results in a reduction of myocardial oxygen requirement and in an increase in myocardial oxygen delivery. In addition, diltiazem maleate has a potent negative chronotropic effect with only a mild negative inotropic effect. This drug is used as an antiarrhythmic and an antianginal agent. ( NCI )]
UMLS (NCI) C0282138 - Organic Chemical
- Pharmacologic Substance
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