.beta.-Pyrazomycin
[A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication. (NCI04) ( NCI )]
UMLS (NCI) C0072661- Nucleic Acid, Nucleoside, or Nucleotide
- Pharmacologic Substance
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