- 1.
- [ ] (UMLS (ICD9CM) C0730521) Less than 24 completed weeks of gestation =Finding
| - 51. 13-CRA/IFN-B
- (UMLS (NCI) C0281419) =Therapeutic or Preventive Procedure
|
- 2. (+ -)-Carbovir
- [An anti-HIV agent that exerts its effects by inhibiting reverse transcriptase. ( NCI )] (UMLS (NCI) C0054727) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
| - 52. 13-CRA/PCB
- (UMLS (NCI) C0796376) Isotretinoin/Procarbazine =Therapeutic or Preventive Procedure ;
|
- 3. (+)-6-((4-Chlorophenyl)-1H-1,2,4-triazol-1-ylmethyl)-1-methyl-1H-benzotriazole
- [A hormone therapy drug used to decrease the production of estrogen. ( NCI )] (UMLS (NCI) C0286224) =Organic Chemical; Pharmacologic Substance
| - 53. 13-CRA/TMZ
- (UMLS (NCI) C0796607) Isotretinoin/Temozolomide =Therapeutic or Preventive Procedure
|
- 4. (+)-Camptothecin
- [alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata; this compound selectively inhibits the nuclear enzyme DNA topoisomerase type I; several semisynthetic analogs of camptothecin have demonstrated antitumor activity. ( CSP )] (UMLS (NCI) C0006812) =Organic Chemical; Pharmacologic Substance =alkaloid;
[AN000] ANTINEOPLASTICS;
indolizine;
=(s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione;
(+)-(4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidino-piperidino)carbonyloxy]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinol-3,14,(4H,12H)-dione;
(s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione | - 54. 13-CRA/VIT-E
- (UMLS (NCI) C0281667) =Therapeutic or Preventive Procedure
|
- 5. (+)-Catechin
- [An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms. ( MSH )] (UMLS (NCI) C0007404) =Organic Chemical; Pharmacologic Substance
| - 55. 14 Carbon
- [An unstable isotope of carbon created when a neutron collides with a nitrogen atom, causing capture of the neutron and release of the proton converting nitrogen to a carbon with fourteen nucleons (6 protons and 8 neutrons). Carbon-14 emits beta particles as it decays and reverts back to nitrogen. ( NCI )] (UMLS (NCI) C0302945) =Indicator, Reagent, or Diagnostic Aid; Element, Ion, or Isotope ;
|
- 6. (+-)-1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone Hydrochloride
- [The hydrochloride salt of an aminoketone antidepressant. The molecular mechanism of the antidepressant effect of bupropion is unknown. This agent does not inhibit monoamine oxidase and, compared to classical tricyclic antidepressants, is a weak blocker of the neuronal uptake of serotonin and norepinephrine. Buproprion also weakly inhibits the neuronal re-uptake of dopamine. ( NCI )] (UMLS (NCI) C0700563) =Organic Chemical; Pharmacologic Substance =1-Propanone, 1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-;
=BUPROPION HYDROCHLORIDE 100 MG;
BUPROPION HYDROCHLORIDE 75 MG;
BUPROPION HYDROCHLORIDE 150 MG | - 56. 17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium
- [A methyl derivative of noroxymorphone with selective, opioid-receptor antagonistic activity. Methylnaltrexone displaces opioids from peripheral opioid receptors in the gastrointestinal tract, the bladder, and the skin, resulting in decreases in opioid-related constipation, urinary retention, and pruritis, respectively. Methylnaltrexone does not cross the blood-brain barrier and does not affect the centrally-mediated analgesic effect of opioids. ( NCI )] (UMLS (NCI) C0066411) =Organic Chemical; Pharmacologic Substance ;
|
- 7. (+-)-1-(4-(4-Chlorophenyl)-2-((2,6-dichlorophenyl)thio)butyl)-1H-imidazole Mononitrate
- [The nitrate salt form of butaconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate interferes with steroid biosynthesis by inhibiting the conversion of lanosterol to ergosterol, thereby changing the fungal cell membrane lipid composition. This alters cell permeability and leads to growth inhibition. Butaconazole nitrate is active against many dermatophytes and yeasts. It also contains antibacterial effects against some gram-positive organisms. ( NCI )] (UMLS (NCI) C0107509) =Organic Chemical; Pharmacologic Substance =butoconazole;
=BUTOCONAZOLE NITRATE 2 % | - 57. 2'3' cyclic nucleotide phosphodiesterase
- [Nucleoside-2',3'-cyclic phosphate nucleotidohydrolase. Enzymes that catalyze the hydrolysis of the 2'- or 3'- phosphate bonds of 2',3'-cyclic nucleotides. Also hydrolyzes nucleoside monophosphates. Includes EC 3.1.4.16 and EC 3.1.4.37. EC 3.1.4.-. ( MSH )] (UMLS (CSP) C0000184) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 8. (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one Hydrochloride
- [antineoplastic cyclin dependent kinase inhibitor. ( CSP )] (UMLS (NCI) C0281603) =Organic Chemical; Pharmacologic Substance =[AN000] ANTINEOPLASTICS;
enzyme inhibitor;
flavone;
| - 58. 2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester
- [fibric acid derivative used in the treatment of hyperlipoproteinemia and hypertriglyceridemia. ( CSP )] (UMLS (NCI) C0009002) =Organic Chemical; Pharmacologic Substance ;
=[CV350] ANTILIPEMIC AGENTS;
butyrate;
Clofibric Acid;
chlorophenoxyacetate |
- 9. (-)-Cholesterol
- [C27H46O, the major fatty steroid alcohol of vertebrate animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. ( CSP )] (UMLS (NCI) C0008377) =Steroid; Biologically Active Substance ;
=cholestane compound;
Cholestenes;
sterol;
Unclassified Ingredient Preparations =hydroxycholesterol;
cholesterol oxide;
SALICYLIC ACID 40% OINTMENT(GM);
BASLE CREAM,TOP;
ALUMINUM ACETATE/ZINC OXIDE PASTE,TOP;
CHOLESTEROL 3 %;
| - 59. 2-CdA/CLB
- (UMLS (NCI) C0281307) =Therapeutic or Preventive Procedure ;
|
- 10. (-)-Cyclophosphamide
- [precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent; used in the treatment of lymphomas, leukemias and other cancers, and as an immunosupressive agent to prevent transplant rejection; its side effect, alopecia, has been used for defleecing sheep; may also cause sterility, birth defects, mutations, and cancer. ( CSP )] (UMLS (NCI) C0010583) =Organophosphorus Compound; Pharmacologic Substance =[AN000] ANTINEOPLASTICS;
phosphamide;
[IM600] IMMUNE SUPPRESSANTS;
Phosphoramide Mustards;
Antineoplastic Alkylating Agent;
=2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine;
CYCLOPHOSPHAMIDE 100 MG;
CYCLOPHOSPHAMIDE 200 MG;
CYCLOPHOSPHAMIDE 500 MG;
CYCLOPHOSPHAMIDE 25 MG;
CYCLOPHOSPHAMIDE 50 MG;
CYCLOPHOSPHAMIDE 2 GM;
CYCLOPHOSPHAMIDE 1 GM;
CYCLOPHOSPHAMIDE 1 GM/VIL;
CYCLOPHOSPHAMIDE 2 GM/VIL | - 60. 2-CdA/CTX/PRED
- (UMLS (NCI) C0678010) =Therapeutic or Preventive Procedure
|
- 11. (4-carboxyphthalato)(1,2-diaminocyclohexane)-platinum(II)
- [A second-generation platinum analog with potential antineoplastic activity. Dacplatinum alkylates DNA at the N-7 position of guanine, thereby producing DNA interstrand crosslinks and DNA strand breaks, and inhibiting DNA replication. (NCI04) ( NCI )] (UMLS (NCI) C0054768) =Organic Chemical; Pharmacologic Substance ;
| - 61. 2-CdA/IDA
- (UMLS (NCI) C0677832) =Therapeutic or Preventive Procedure ;
|
- 12. (CH3)2CHCH2CH3
- [An organic, branched-chain alkane with five carbon atoms. ( NCI )] (UMLS (NCI) C0083072) =Organic Chemical
| - 62. 2-CdA/VP-16
- (UMLS (NCI) C0392926) =Therapeutic or Preventive Procedure ;
|
- 13. *Catalytic Activity
- (UMLS (HL7) C1547012) =Quantitative Concept =Kind of quantity;
| - 63. 2-Chlorallyl Diethyldithiocarbamate
- [A synthetic, amber oil that is slightly soluble in water and soluble in most organic solvents. Sulfallate products are no longer used in the United States. Therefore, the potential for human exposure is low. When heated to decomposition, sulfallate emits toxic fumes of hydrochloric acid, nitrogen, and sulfur oxides. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0054976) =Organic Chemical; Pharmacologic Substance ;
|
- 14. *Catalytic Concentration
- (UMLS (HL7) C1264648) =Quantitative Concept =Kind of quantity;
| - 64. 2-Chloro-1,3-butadiene
- [A colorless, flammable, carcinogenic, chlorinated hydrocarbon with a pungent, ethereal odor. Chloroprene is used as a chemical intermediate in the manufacture of neoprene rubber. Exposure to this substance causes damage to the skin, lungs, CNS, kidneys, liver and depression of the immune system. Chloroprene is a mutagen and carcinogen in animals and is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0008267) =Organic Chemical; Hazardous or Poisonous Substance ;
|
- 15. *Catalytic Content
- (UMLS (HL7) C1264656) =Quantitative Concept =Kind of quantity;
| - 65. 2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
- [extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate. ( CSP )] (UMLS (NCI) C0014277) =Organic Chemical; Pharmacologic Substance ;
=[CN200] ANESTHETICS;
Methyl Ethers;
[CN201] ANESTHETICS INHALATION;
haloether =ENFLURANE 99.9 % |
- 16. *Catalytic Fraction
- (UMLS (HL7) C1305363) =Functional Concept; ;
=Kind of quantity;
| - 66. 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine
- [phenothiazine derivative used chiefly as an antiemetic. ( CSP )] (UMLS (NCI) C0033229) =Organic Chemical; Pharmacologic Substance =[GA700] ANTIEMETICS;
Phenothiazine;
[CN700] ANTIPSYCHOTICS;
=2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine Edisylate;
Prochlorperazine Dimaleate;
2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine Edisylate;
Prochlorperazine Dimaleate;
PROCHLORPERAZINE 10 MG;
PROCHLORPERAZINE 2.5 MG;
PROCHLORPERAZINE 25 MG;
PROCHLORPERAZINE 5 MG/ML;
PROCHLORPERAZINE 5 MG |
- 17. *Catalytic Rate
- (UMLS (HL7) C1264668) =Quantitative Concept =Kind of quantity;
| - 67. 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine Edisylate
- [The edisylate salt form of prochlorperazine, a derivative of phenothiazine with antipsychotic and antiemetic properties. Prochlorperazine edisylate blocks postsynaptic dopamine receptors in cortical and limbic areas of the brain, thereby preventing the excess of dopamine in the brain. This leads to a reduction in psychotic symptoms, including hallucinations and delusions. Prochlorperazine edisylate appears to exert its antiemetic activity by blocking the dopamine and histamine receptors in the chemical trigger zone (CTZ) in the brain, thereby relieving nausea and vomiting. ( NCI )] (UMLS (NCI) C0033230) =Organic Chemical; Pharmacologic Substance =2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine;
=PROCHLORPERAZINE EDISYLATE 5 MG/ML;
PROCHLORPERAZINE EDISYLATE 5 MG/5ML;
|
- 18. *Coefficient
- [A constant number that serves as a measure of some property or characteristic. ( NCI )] (UMLS (HL7) C1707429) Coefficient =Quantitative Concept ;
=Kind of quantity;
| - 68. 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine
- [prototypical phenothiazine antipsychotic drug; antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors; chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup. ( CSP )] (UMLS (NCI) C0008286) =Organic Chemical; Pharmacologic Substance ;
=Phenothiazine;
[CN700] ANTIPSYCHOTICS;
[CN701] PHENOTHIAZINES/RELATED, ANTIPSYCHOTICS;
=2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine Monohydrochloride;
CHLORPROMAZINE 100 MG;
CHLORPROMAZINE 25 MG |
- 19. *Constant
- (UMLS (HL7) C1547014) =Quantitative Concept =Kind of quantity;
| - 69. 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine Monohydrochloride
- [The hydrochloride salt form of chlorpromazine, a phenothiazine and traditional antipsychotic agent with anti-emetic activity. Chlorpromazine hydrochloride exerts its antipsychotic effect by blocking postsynaptic dopamine receptors in cortical and limbic areas of the brain, thereby preventing the excess of dopamine in the brain. This leads to a reduction in psychotic symptoms, such as hallucinations and delusions. Chlorpromazine hydrochloride appears to exert its anti-emetic activity by blocking the dopamine receptors in the chemical trigger zone (CTZ) in the brain, thereby relieving nausea and vomiting. ( NCI )] (UMLS (NCI) C0355077) =Organic Chemical; Pharmacologic Substance =2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine;
=CHLORPROMAZINE HYDROCHLORIDE 25 MG;
CHLORPROMAZINE HYDROCHLORIDE 100 MG;
CHLORPROMAZINE HYDROCHLORIDE 10 MG;
CHLORPROMAZINE HYDROCHLORIDE 10 MG/5ML;
CHLORPROMAZINE HYDROCHLORIDE 150 MG;
CHLORPROMAZINE HYDROCHLORIDE 200 MG;
CHLORPROMAZINE HYDROCHLORIDE 30 MG;
CHLORPROMAZINE HYDROCHLORIDE 30 MG/ML;
CHLORPROMAZINE HYDROCHLORIDE 75 MG;
CHLORPROMAZINE HYDROCHLORIDE 50 MG;
CHLORPROMAZINE HYDROCHLORIDE 100 MG/ML;
CHLORPROMAZINE HYDROCHLORIDE 25 MG/ML;
|
- 20. 1 carbon compound
- [ ] (UMLS (CSP) C0597700) =Organic Chemical ;
=Organic Chemical;
| - 70. 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine Succinate(1:1)
- [The succinate salt form of loxapine, a tricyclic dibenzoxazepine antipsychotic agent with antiemetic, sedative, anticholinergic, and antiadrenergic actions. Loxapine succinate exerts its actions by blocking the dopamine receptors at postsynaptic receptor sites in the limbic system, cortical system and basal ganglia, thereby reducing the hallucinations and delusions that are associated with schizophrenia. This agent also exerts extrapyramidal side effects. ( NCI )] (UMLS (NCI) C0024057) =Organic Chemical; Pharmacologic Substance ;
=LOXAPINE;
=LOXAPINE SUCCINATE 10 MG;
LOXAPINE SUCCINATE 25 MG;
LOXAPINE SUCCINATE 50 MG;
LOXAPINE SUCCINATE 5 MG;
|
- 21. 1 carbon transferase
- [ ] (UMLS (CSP) C0597701) =Amino Acid, Peptide, or Protein; Enzyme =EC 2;
=EC 2.1.1;
formininotransferase;
carboxyltransferase/carbamoyltransferase | - 71. 2-Chloro-4-Phenylphenol
- (UMLS (NCI) C0045999) =Organic Chemical; Pharmacologic Substance ;
|
- 22. 1-(2-chloroethyl)-1-nitroso-3-(D-glucos-2-yl)urea
- [A glucose-linked chloroethylnitrosourea with potential antineoplastic activity. Chlorozotocin alkylates DNA and proteins, induces the formation of interstrand DNA and DNA-protein crosslinks, and causes DNA strand breakage, thereby damaging DNA and resulting in cell death. This agent has been shown to exhibit antitumor and immunomodulatory effects in cell lines and animal models. Chlorozotocin is a mutagen and is less myelotoxic than other nitrosoureas. (NCI04) ( NCI )] (UMLS (NCI) C0055465) =Organic Chemical; Antibiotic
| - 72. 2-Chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine
- [A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called nucleoside analogs. ( NCI )] (UMLS (NCI) C0092777) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
|
- 23. 1-(2-Chloroethyl)-3-(2,6-Dioxo-3-Piperidyl)-1-Nitrourea
- [A chloroethylnitrosourea compound and an alkylating agent with antineoplastic property. PCNU inhibits DNA synthesis by alkylating DNA and causing DNA cross links, thereby inducing apoptosis. In addition, this agent may be associated with pulmonary, hepatic, and hematologic toxicities. Unlike other nitrosoureas, PCNU has strong alkylating while weak carbamoylating activity. ( NCI )] (UMLS (NCI) C0070165) =Organic Chemical; Pharmacologic Substance
| - 73. 2-Chloroethyl-3-Sarcosinamide-1-Nitrosourea
- [An anticancer drug that belongs to the family of drugs called alkylating agents. ( NCI )] (UMLS (NCI) C0045644) =Organic Chemical; Pharmacologic Substance ;
|
- 24. 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
- [An anticancer drug that belongs to the family of drugs called alkylating agents. ( NCI )] (UMLS (NCI) C0036637) =Organic Chemical; Pharmacologic Substance ;
| - 74. 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid
- [A synthetic, triterpenoid compound with anticancer and anti-inflammatory activities. CDDO blocks the synthesis of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), two enzymes involved in inflammation and carcinogenesis. This agent also inhibits the interleukin-1 (IL-1)-induced expression of the pro-inflammatory proteins matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-13 (MMP-13) and the expression of Bcl-3, an IL-1-responsive gene that preferentially contributes to MMP-1 gene expression. ( NCI )] (UMLS (NCI) C0762434) 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid;
CDDO;
=Organic Chemical; Pharmacologic Substance |
- 25. 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
- [cytotoxic alkylating agent of the nitrosourea group used as an antineoplastic. ( CSP )] (UMLS (NCI) C0023972) =Organic Chemical; Pharmacologic Substance =[AN000] ANTINEOPLASTICS;
nitrosourea;
Antineoplastic Alkylating Agent;
=LOMUSTINE 10 MG;
LOMUSTINE 100 MG;
LOMUSTINE 40 MG;
LOMUSTINE 300 MG;
| - 75. 21-Chloro-6alpha,9-difluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
- [The propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses across cell membranes to interact with cytoplasmic corticosteroid receptors located in both the dermal and intradermal cells, thereby activates gene expression of anti-inflammatory proteins mediated via corticosteroid receptor respond element. Specifically, this agent induces phospholipase A2 inhibitory proteins, which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes. As a result, halobetasol reduces edema, erythema and pruritus through its cutaneous effects on vascular dilation and permeability. ( NCI )] (UMLS (NCI) C0098735) =Steroid; Pharmacologic Substance ;
=CLOBETASOL;
Halobetasol =Halobetasol;
HALOBETASOL PROPIONATE 0.05 % |
- 26. 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine
- (UMLS (NCI) C0533112) =Organic Chemical; Pharmacologic Substance
| - 76. 21-Chloro-9-fluoro-11beta,16alpha,17-trihydroxypregn-4-ene-3,20-dione Cyclic 16,17-Acetal with Acetone
- [A topical, synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. Halcinonide exerts its effect by interacting with specific intracellular receptors, and the ligand-receptor complex subsequently modulates gene expressions via the typical glucocorticoid signalling pathway. This results in the synthesis of certain anti-inflammatory proteins as well as in synthesis inhibition of certain inflammatory mediators. Consequently, an overall reduction in chronic inflammation and autoimmune reactions are accomplished. (NCI05) ( NCI )] (UMLS (NCI) C0018513) =Steroid; Pharmacologic Substance =Pregnenediones;
[DE200] ANTI-INFLAMMATORY, TOPICAL =HALCINONIDE 0.025 %;
HALCINONIDE 0.1 %;
|
- 27. 1-(4-(2-Cyclopropylmethoxy)ethyl)phenoxy)-3-))1-methylethyl)amino)-2-propanol
- [A racemic mixture and selective beta-1 adrenergic receptor antagonist with antihypertensive and anti-glaucoma activities and devoid of intrinsic sympathomimetic activity. Betaxolol selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart, thereby decreasing cardiac contractility and rate. This leads to a reduction in cardiac output and lowers blood pressure. When applied topically in the eye, this agent reduces aqueous humor secretion and lowers the intraocular pressure (IOP). In addition, betaxolol prevents the release of renin, a hormone secreted by the kidneys that causes constriction of blood vessels. ( NCI )] (UMLS (NCI) C0005320) =Organic Chemical; Pharmacologic Substance ;
| - 77. 24 COMP WEEKS GESTATION
- [ ] (UMLS (ICD9CM) C0730522) 24 completed weeks of gestation =Finding
|
- 28. 1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-1-H-indole-3-acetic acid
- [non-steroidal anti-inflammatory agent that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids; also inhibits the motility of polymorphonuclear leukocytes. ( CSP )] (UMLS (NCI) C0021246) =Organic Chemical; Pharmacologic Substance =Indole;
cyclooxygenase inhibitor;
methoxyindole;
[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC;
immunomodulator;
=KETOROLAC TROMETHAMINE;
Indomethacin Sodium;
INDOMETHACIN POWDER (GM);
Indomethacin Sodium;
INDOMETHACIN 25 MG;
INDOMETHACIN 25 MG/5ML;
INDOMETHACIN 50 MG;
INDOMETHACIN 75 MG;
| - 78. 25-26 COMP WKS GESTATION
- [ ] (UMLS (ICD9CM) C1135242) 25-26 completed weeks of gestation;
=Temporal Concept |
- 29. 1-(5-Chloro-3-(2-chlorophenyl)-1-(3,4-dimethoxybenzenesulfonyl)-3-hydroxy-2,3-dihydro-1H-indole-2-carbonyl)pyrrolidine-2-carboxamide
- (UMLS (NCI) C0218068) =Organic Chemical; Pharmacologic Substance ;
| - 79. 27-28 COMP WKS GESTATION
- [ ] (UMLS (ICD9CM) C1135243) 27-28 completed weeks of gestation;
=Temporal Concept |
- 30. 1-Chloro-2,3-epoxypropane
- [A volatile and flammable, clear, colorless, liquid, chlorinated cyclic ether with an irritating, chloroform-like odor that emits toxic fumes of hydrochloric acid and other chlorinated compounds when heated to decomposition. Epichlorohydrin is used in the manufacture of epoxy resins, synthetic glycerin and elastomers. Exposure to epichlorohydrin irritates the eyes, skin and respiratory tract, and can cause chemical pneumonitis, pulmonary edema, and renal lesions. This substance also affects the blood. Epichlorohydrin is reasonably anticipated to be a human carcinogen and may be associated with an increased risk of developing respiratory cancer. (NCI05) ( NCI )] (UMLS (NCI) C0014486) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 80. 29-30 COMP WKS GESTATION
- [ ] (UMLS (ICD9CM) C1135244) 29-30 completed weeks of gestation;
=Temporal Concept |
- 31. 1-Chloroisobutylene
- [A clear, colorless, highly volatile and flammable liquid chlorinated hydrocarbon that emits highly toxic fumes of hydrochloric acid and other chlorinated compounds when heated to decomposition. Dimethylvinyl chloride is exclusively used for research purposes in organic synthesis and in the production of isobutylene compounds. This substance is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0044333) =Organic Chemical; Pharmacologic Substance ;
| - 81. 2C4
- [A humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the HER-2 tyrosine kinase receptor. Binding of the antibody to the dimerization domain of the HER-2 tyrosine kinase receptor protein directly inhibits the ability of the HER-2 tyrosine kinase receptor protein (the most common pairing partner) to dimerize with other HER tyrosine kinase receptor proteins; inhibiting receptor protein dimerization prevents the activation of HER signaling pathways, resulting in tumor cell apoptosis. (NCI04) ( NCI )] (UMLS (NCI) C1328025) 2C4 Antibody;
MoAb 2C4;
Monoclonal Antibody 2C4;
Pertuzumab;
rhuMAb2C4 =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor |
- 32. 1-cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol Hydrochloride
- [The hydrochloride salt form of procyclidine, with anticholinergic properties. Procyclidine hydrochloride competitively binds to striatal cholinergic receptors, thereby diminishing acetylcholine activity and ultimately reducing the frequency and severity of akinesia, rigidity, and tremor associated with uncontrollable body movements. In addition, this agent may block the re-uptake of dopamine by nerve terminals, thereby increasing dopamine activity. ( NCI )] (UMLS (NCI) C0546874) =Organic Chemical; Pharmacologic Substance =Procyclidine;
=PROCYCLIDINE HYDROCHLORIDE 5 MG;
| - 82. 2CDA
- [An anticancer drug that belongs to the family of drugs called antimetabolites. ( NCI )] (UMLS (NCI) C0092801) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance =2-Chloroadenosine;
[AN300] ANTINEOPLASTICS, ANTIMETABOLITES;
[AN000] ANTINEOPLASTICS;
Deoxyadenosines;
[IM600] IMMUNE SUPPRESSANTS;
deoxyadenosine =CLADRIBINE 1 MG/ML;
|
- 33. 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid
- [An anti-infection drug that is also being studied in bladder cancer chemotherapy. ( NCI )] (UMLS (NCI) C0008809) =Organic Chemical; Pharmacologic Substance =Quinolones;
antibacterial agent;
[AM900] ANTI-INFECTIVES, OTHER;
[OP201] ANTIBACTERIALS, TOPICAL OPHTHALMIC =1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid, Monohydrochloride, Monohydrate;
CIPROFLOXACIN 10 MG/ML;
CIPROFLOXACIN 2 MG/ML;
24 HR Ciprofloxacin 500 MG Extended Release Tablet;
24 HR Ciprofloxacin 1000 MG Extended Release Tablet | - 83. 3'-C-Ethynylcytidine
- (UMLS (NCI) C0533115) =Organic Chemical; Pharmacologic Substance
|
- 34. 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid, Monohydrochloride, Monohydrate
- [The hydrochloride salt form of ciprofloxacin, a fluoroquinolone related to nalidixic acid with antibacterial activity. Ciprofloxacin hydrochloride exerts its bactericidal effect by interfering with the bacterial DNA gyrase, thereby inhibiting the DNA synthesis and preventing bacterial cell growth. ( NCI )] (UMLS (NCI) C0282104) =Organic Chemical; Antibiotic ;
=1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid;
=CIPROFLOXACIN HYDROCHLORIDE 250 MG/5ML;
CIPROFLOXACIN HYDROCHLORIDE 500 MG/5ML;
CIPROFLOXACIN HYDROCHLORIDE 02 %;
CIPROFLOXACIN HYDROCHLORIDE 250 MG;
CIPROFLOXACIN HYDROCHLORIDE 500 MG;
CIPROFLOXACIN HYDROCHLORIDE 750 MG;
CIPROFLOXACIN HYDROCHLORIDE 100 MG;
CIPROFLOXACIN HYDROCHLORIDE 0.3 %;
| - 84. 3'5' cyclic nucleotide phosphodiesterase
- [Enzymes that catalyze the hydrolysis of CYCLIC AMP to form adenosine 5'-phosphate. The enzymes are widely distributed in animal tissue and control the level of intracellular cyclic AMP. Many specific enzymes classified under this heading demonstrate additional spcificity for 3',5'-cyclic IMP and CYCLIC GMP. ( MSH )] (UMLS (CSP) C0000359) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 35. 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid
- [A synthetic 8-methoxyfluoroquinolone with antibacterial activity against a wide range of gram-negative and gram-positive microorganisms. Gatifloxacin exerts its effect through inhibition of DNA gyrase, an enzyme involved in DNA replication, transcription and repair, and inhibition of topoisomerase IV, an enzyme involved in partitioning of chromosomal DNA during bacterial cell division. ( NCI )] (UMLS (NCI) C0753645) Gatifloxacin;
GATIFLOXACIN PREPARATION =Organic Chemical; Antibiotic ;
=[AM900] ANTI-INFECTIVES, OTHER;
Unclassified Ingredients =GATIFLOXACIN 10 MG/ML;
GATIFLOXACIN 200 MG;
GATIFLOXACIN 400 MG;
GATIFLOXACIN 2 MG/ML;
GATIFLOXACIN 0.3 %;
| - 85. 3'5'-cyclic ester of AMP
- [adenine nucleotide containing one phosphate group which is esterified to both the 3' and 5' positions of the sugar moiety; it is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones. ( CSP )] (UMLS (NCI) C0001455) =Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance ;
|
- 36. 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole
- [A synthetic, imidazole derivate with broad-spectrum, antifungal activity. Clotrimazole inhibits biosynthesis of sterols, particularly ergosterol, an essential component of the fungal cell membrane, thereby damaging and affecting the permeability of the cell membrane. This results in leakage and loss of essential intracellular compounds, and eventually causes cell lysis. ( NCI )] (UMLS (NCI) C0009074) =Organic Chemical; Pharmacologic Substance =imidazole;
[DE102] ANTIFUNGAL, TOPICAL;
[GU300] ANTI-INFECTIVES, VAGINAL;
[NT900] NASAL AND THROAT, TOPICAL, OTHER =CLOTRIMAZOLE 10 MG;
CLOTRIMAZOLE 100 MG;
CLOTRIMAZOLE 200 MG;
CLOTRIMAZOLE 1 % | - 86. 3,5 cyclic AMP synthetase
- [An enzyme of the lyase class that catalyzes the formation of CYCLIC AMP and pyrophosphate from ATP. EC 4.6.1.1. ( MSH )] (UMLS (CSP) C0001492) =Amino Acid, Peptide, or Protein; Enzyme
|
- 37. 1-[(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine
- [A synthetic piperazine with anti-emetic, sedative and histamine H1antagonistic properties. Meclizine blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial and gastrointestinal smooth muscles, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscles. Meclizine hydrochloride may exert its antiemetic effects by its anticholinergic actions or due to a direct effect on the medullary chemoreceptive trigger zone. ( NCI )] (UMLS (NCI) C0025039) =Organic Chemical; Pharmacologic Substance ;
=Benzhydryl Compounds;
Piperazines;
[CN550] ANTIVERTIGO AGENTS;
=1-[(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine Dihydrochloride Monohydrate | - 87. 3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine
- [A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. ( NCI )] (UMLS (NCI) C0009010) =Organic Chemical; Pharmacologic Substance ;
=[CN601] TRICYCLIC ANTIDEPRESSANTS;
Dibenzazepines =3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine monohydrochloride;
|
- 38. 1-[(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine Dihydrochloride Monohydrate
- [The hydrochloride salt form of meclizine, a synthetic piperazine with anti-emetic, sedative and histamine H1 antagonistic properties. Meclizine hydrochloride blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial and gastrointestinal smooth muscles, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscles. Meclizine hydrochloride may exert its antiemetic effects by its anticholinergic actions or due to a direct effect on the medullary chemoreceptive trigger zone. ( NCI )] (UMLS (NCI) C0282227) =Organic Chemical; Pharmacologic Substance =1-[(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine;
=MECLIZINE HYDROCHLORIDE 15 MG;
MECLIZINE HYDROCHLORIDE 50 MG;
MECLIZINE HYDROCHLORIDE 12.5 MG;
MECLIZINE HYDROCHLORIDE 25 MG;
MECLIZINE HYDROCHLORIDE 30 MG;
| - 88. 3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine monohydrochloride
- [The hydrochloride salt form of clomipramine, a tertiary amine salt derivative of dibenzazepine. Clomipramine hydrochloride is a tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. ( NCI )] (UMLS (NCI) C0282107) =Organic Chemical; Pharmacologic Substance ;
=3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine;
=CLOMIPRAMINE HYDROCHLORIDE 25 MG;
CLOMIPRAMINE HYDROCHLORIDE 50 MG;
CLOMIPRAMINE HYDROCHLORIDE 75 MG |
- 39. 1-[2-{(4-chloro-phenyl)methoxy}-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole Mononitrate
- [An imidazole derivative and broad-spectrum antimycotic agent with fungistatic properties. Econazole nitrate inhibits biosynthesis of ergosterol, thereby damaging the fungal cell wall membrane and altering its permeability which leads to a loss of essential intracellular components. In addition, econazole nitrate inhibits biosynthesis of triglycerides and phospholipids and inhibits oxidative and peroxidative enzyme activity which may contribute to cellular necrosis and cell death. Econazole nitrate is also active against some gram positive bacteria. This antifungal agent is used in the treatment various dermatomycoses. ( NCI )] (UMLS (NCI) C0546862) =Organic Chemical; Pharmacologic Substance =ECONAZOLE;
=ECONAZOLE NITRATE 1 %;
| - 89. 3-Chloroprocainamide
- [A third-generation DNA repair inhibitor that modulates multi-drug resistance. ( NCI )] (UMLS (NCI) C0649622) =Organic Chemical
|
- 40. 1-[4-Chloroanilino]-4-[4-pyridylmethyl]phthalazine Succinate
- [An orally bioavailable anilinophthalazine with potential antineoplastic activity. Vatalanib binds to and inhibits the protein kinase domain of vascular endothelial growth factor receptors 1 and 2; both receptor tyrosine kinases are involved in angiogenesis. This agent also binds to and inhibits related receptor tyrosine kinases, including platelet-derived growth factor (PDGF) receptor, c-Kit, and c-Fms. ( NCI )] (UMLS (NCI) C0912586) 1-Phthalazinamine, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, butanedioate (1:1);
Butanedioic Acid, Compd. with N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine (1:1);
PTK 787/ZK 222584;
VATALANIB =Organic Chemical; Pharmacologic Substance | - 90. 3-[(3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene]-2-indolinone
- (UMLS (NCI) C0538429) =Organic Chemical; Pharmacologic Substance
|
- 41. 1-[[5-[[2-(Carboxymethyl)-3-[[decahydro-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]methoxy]-4-methoxy-1,4-dioxobutoxy]methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]methoxy]-1,2,3-propanetricarboxylic Acid, 1,2-Dimethyl Ester
- (UMLS (NCI) C0111136) =Organic Chemical
| - 91. 3.2% Citrate
- (UMLS (HL7) C1550056) =Organic Chemical; Biomedical or Dental Material =Additive/Preservative;
|
- 42. 10-((3-Chloro-4-methoxyphenyl)methyl)-6-methyl-3-(2-methylpropyl)-16-(1-(3-phenyloxiranyl)ethyl)-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone
- [The cryptophycins are a family of 16-membered macrolide antimitotic agents isolated from the cyanobacteria Nostoc sp. The mechanism of anticancer activity of the cryptophycins has been associated with their destabilization of microtubules and induction of bcl-2 phosphorylation leading to apoptosis. Cryptophycins demonstrated activity against the wide spectrum of solid tumors including those that overexpress the multidrug resistance efflux pump P-glycoprotein. (NCI) ( NCI )] (UMLS (NCI) C0257217) =Amino Acid, Peptide, or Protein; Pharmacologic Substance
| - 92. 3.2% Citrate
- [A 3.2% solution of Sodium Citrate in water. Used as a blood preservative ( HL7V3.0 )] (UMLS (HL7) C1561458) =Intellectual Product =MaterialEntityAdditive;
|
- 43. 10-chloro-4-hydroxy-6-methyl-2-phenyl-3,6-diazabicyclo[5.4.0]undeca-2,8,10,12-tetraen-5-one
- [A benzodiazepine derivative with antidepressant, sedative, hypnotic and anticonvulsant properties. Temazepam potentiates the inhibitory activities of gamma-aminobutyric acid (GABA) by binding to the GABA receptor, located in the limbic, neocortical and mesencephalic reticular system. This increases the frequency of chloride channel opening events, allowing the flow of chloride ions into the neuron leading to membrane hyperpolarization and decreases neuronal excitability. ( NCI )] (UMLS (NCI) C0039468) =Organic Chemical; Pharmacologic Substance =Benzodiazepinones;
[CN302] BENZODIAZEPINE DERIVATIVE, SEDATIVES/HYPNOTICS =TEMAZEPAM 15 MG;
TEMAZEPAM 30 MG;
TEMAZEPAM 7.5 MG;
| - 93. 3.8% Citrate
- (UMLS (HL7) C1550057) =Organic Chemical; Biomedical or Dental Material =Additive/Preservative;
|
- 44. 10^9 Cells/L
- [A unit of cell concentration expressed as a number of cells in billions in unit volume equal to one liter. ( NCI )] (UMLS (NCI) C0456524) =Quantitative Concept
| - 94. 3.8% Citrate
- [A 3.8% solution of Sodium Citrate in water. Used as a blood preservative ( HL7V3.0 )] (UMLS (HL7) C1561459) =Intellectual Product =MaterialEntityAdditive;
|
- 45. 13 cis retinoate
- [a topical dermatologic agent that is used in the treatment of acne vulgaris and several other skin diseases. ( CSP )] (UMLS (CSP) C0022265) =Organic Chemical; Pharmacologic Substance =Retinoic Acid Agent;
retinoate;
[DE751] ANTIACNE AGENTS, SYSTEMIC;
=ISOTRETINOIN 10 MG;
ISOTRETINOIN 40 MG;
ISOTRETINOIN 20 MG;
| - 95. 31-32 COMP WKS GESTATION
- [ ] (UMLS (ICD9CM) C1135245) 31-32 completed weeks of gestation;
=Temporal Concept |
- 46. 13-CRA/5-FU/IFN-A/IL-2
- (UMLS (NCI) C0338195) =Therapeutic or Preventive Procedure ;
| - 96. 311C90
- (UMLS (NCI) C0289361) =Organic Chemical; Pharmacologic Substance ;
|
- 47. 13-CRA/FLUT/LEUP
- (UMLS (NCI) C0281718) =Therapeutic or Preventive Procedure
| - 97. 33-34 COMP WKS GESTATION
- [ ] (UMLS (ICD9CM) C1135246) 33-34 completed weeks of gestation;
=Temporal Concept |
- 48. 13-CRA/IFN-A
- (UMLS (NCI) C0338122) =Therapeutic or Preventive Procedure ;
| - 98. 35-36 COMP WKS GESTATION
- [ ] (UMLS (ICD9CM) C1135247) 35-36 completed weeks of gestation;
=Temporal Concept |
- 49. 13-CRA/IFN-A/IL-2
- (UMLS (NCI) C0338194) =Therapeutic or Preventive Procedure ;
| - 99. 4-(3Chloro-4-flurophenylamine)-7-methoxy-6(3-(4morpholinyl)quinazoline
- [A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors. Also called ZD 1839. ( NCI )] (UMLS (NCI) C1122962) 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-4-morpholin] propoxy];
Gefitinib;
GEFITINIB PREPARATION =Organic Chemical; Pharmacologic Substance ;
=[AN000] ANTINEOPLASTICS;
Unclassified Ingredients =GEFITINIB 250 MG |
- 50. 13-CRA/IFN-A/VIT-E
- (UMLS (NCI) C0678004) =Therapeutic or Preventive Procedure
| - 100. 4-carboxyphenyl retinamide
- [A synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Carboxyphenyl retinamide induces cell differentiation and inhibits tumor cell growth and carcinogenesis. This agent may also induce cell cycle arrest in the G1 phase in some cancer cell types. (NCI04) ( NCI )] (UMLS (NCI) C0067533) =Organic Chemical; Pharmacologic Substance
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