[A potential regulator of transcription, WT1 belongs to the EGR family of C2H2 zinc-finger proteins and binds to the DNA sequence 5'-CGCCCCCGC-3'. Inactivation of WT1 is one cause of Wilm's Tumor, an embryonal malignancy of the kidney. Defects in WT1 are also associated with Denys-Drash Syndrome (DDS) and Diffuse Mesangial Sclerosis (DMS). (from SWISS-PROT P19544, OMIM 194070, and NCI) ( NCI )] (UMLS (NCI) C0148873) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;