[A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma. (NCI04) ( NCI )] (UMLS (NCI) C0081408) =Organic Chemical; Pharmacologic Substance =Hydroxycarbamide; [RE108] ANTIASTHMA, ANTILEUKOTRIENES =ZILEUTON 600 MG;
[A synthetic indolocarbazole with antineoplastic activity. Edotecarin inhibits the enzyme topoisomerase I through stabilization of the DNA-enzyme complex and enhanced single-strand DNA cleavage, resulting in inhibition of DNA replication and decreased tumor cell proliferation. (NCI04) ( NCI )] (UMLS (NCI) C1328673) Edotecarin; =Organic Chemical; Pharmacologic Substance