- 1. 1(2H)-Pyrimidinecarboxamide, 5-fluoro-N-hexyl-3,4-dihydro-2,4-dioxo-
- [An antimetabolite (pyrimidine analogue) antineoplastic derivative of 5-fluorouracil. (NCI) ( NCI )] (UMLS (NCI) C0044401) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
| - 9. 2(1H)-pyrimidinone, tetrahydro-4-hydroxy-1-beta-D-ribofuranosyl-
- [A synthetic pyrimidine nucleoside analogue with biomodulating activity. Tetrahydrouridine increases the efficacy of the radiosensitizer cytochlor (5-chloro-2'-deoxycytidine) by inhibiting the enzyme deoxycytidine monophosphate (dCMP) deaminase and preventing the premature deamination of the cytochlor metabolite 5-chloro-2'-deoxycytidine monophosphate (CldCMP) to 5-chloro-2'-deoxyuridine monophosphate (CldUMP); in turn, this increases tumor concentrations of CldUMP which is then further anabolized and incorporated selectively into tumor DNA as CldU (5-chloro-2'-deoxyuridine). (NCI04) ( NCI )] (UMLS (NCI) C0039677) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
|
- 2. 15H-Pyrrolol[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotri-cosine, Cyclic Peptide Deriv. (9CI)
- [A cyclic depsipeptide extracted from the Caribbean tunicate Trididemnum cyanophorum. Didemnin B activates caspase, thereby inducing apoptosis, and prevents eukaryotic elongation factor 2 (eEF-2)-dependent translocation, thereby inhibiting protein synthesis. This agent also has immunosuppressive and antiviral properties. (NCI04) ( NCI )] (UMLS (NCI) C0936059) 1-Oxoheptyl]oxy]-2,5-dimethyl-1,3-dioxohexyl]-L-leucyl]- L-prolyl]-N,O-dimethyl-, .phi.-lactone (9CI);
Didemnin;
Didemnin B;
L-Tyrosine, N-[1-[N-[4-[[3-hydroxy-4-[[N-[N-[1-(2-hydroxy-1-oxopropyl)- L-prolyl]-N-methyl-L-leucyl]-L-threonyl]amino-5-methyl- 1-oxoheptyl]oxy]-2,5-dimethyl-1,3-dioxohexyl]-L-leucyl]- L-prolyl]-N,O-dimethyl-, .phi.-lactone (9CI);
L-Tyrosine, N-[1-[N-[4-[[3-Hydroxy-4-[[N-[N-[1-(2-hydroxy-1-oxopropyl)- L-prolyl]-N-methyl-L-leucyl]-L-threonyl]amino-5-methyl-1-oxoheptyl]oxy]-2,5-dimethyl-1,3-dioxohexyl]-L-leucyl]- L-prolyl]-N,O-dimethyl-, .phi.-lactone (9CI);
=Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
| - 10. 2H-pyran-2-one,5,6-dihydro-6-(3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11,-tridecatetraenyl)-,trans
- [An anti-tumor antibiotic isolated from the bacterium Streptomyces pulveraceus. Fostriecin inhibits topoisomerase II catalytic activity, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis in various malignant cell types. This agent also inhibits serine/threonine protein phosphatase type 2A in some tumor cell types, thereby interfering with cellular proliferation and differentiation. (NCI04) ( NCI )] (UMLS (NCI) C0118175) =Organic Chemical; Pharmacologic Substance
|
- 3. 1H-Pyrazole, 4-methyl-
- [A pyrazole with competitive alcohol dehydrogenase inhibitor activity. Fomepizole prevents the metabolism of ethylene glycol and methanol by alcohol dehydrogenase, thereby inhibiting the formation of their toxic metabolites, glycolate and oxalate (from ethylene glycol), and formic acid (from methanol). Fomepizole is indicated for use as an antidote in ethylene glycol and methanol poisoning. (NCI05) ( NCI )] (UMLS (NCI) C0048504) =Organic Chemical; Pharmacologic Substance =Pyrazole Compound;
1H-Pyrazole, 4-methyl-;
[AD900] ANTIDOTES/DETERRENTS, OTHER;
=1H-Pyrazole, 4-methyl-;
FOMEPIZOLE 1 GM/ML;
| - 11. 4H-Pyrano(2,3-b)(1,4)benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, Dihydrochloride,(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-
- [The hydrochloride salt form of spectinomycin, an aminocyclitol antibiotic derived from Streptomyces spectabilis with antibacterial property. Spectinomycin hydrochloride binds to the bacterial 30S ribosomal subunit, thereby inhibiting peptide elongation and protein synthesis, consequently leading to bacterial cell death. ( NCI )] (UMLS (NCI) C0887525) Spectinomycin Dihydrochloride;
SPECTINOMYCIN HYDROCHLORIDE;
Spectinomycin Hydrochloride Anhydrous;
SPECTINOMYCIN HYDROCHLORIDE PREPARATION;
Spectogard;
=Organic Chemical; Antibiotic ;
=SPECTINOMYCIN;
=SPECTINOMYCIN HYDROCHLORIDE 2 GM/VIL |
- 4. 1H-Pyrido(4,3-b)indol-1-one, 2,3,4,5-tetrahydro-5-methyl-2((5-methyl-1H-imidazol-4-yl)methyl)-, Monohydrochloride
- [The chloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron hydrochloride blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system, particularly on enteric and nociceptive sensory neurons. Alosteron hydrochloride affects the regulation of visceral pain, decreases gastrointestinal contraction and motility, and decreases gastrointestinal secretions. This drug is used to treat diarrhea-predominant irritable bowel syndrome in women. (NCI05) ( NCI )] (UMLS (NCI) C0291771) =Organic Chemical; Pharmacologic Substance =alosetron;
| - 12. 4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylic Acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, Disodium Salt
- [The sodium salt form of nedocromil, a pyranoquinolone derivative with anti-inflammatory properties. Nedocromil sodium inhibits the activation and release of inflammatory mediators (leukotrienes, histamine and prostaglandins) from a variety of cells involved in hypersensitivity reactions, including mast cells, eosinophils, neutrophils, macrophages, monocytes and platelets. As a result, nedocromil sodium inhibits both immediate and late bronchoconstriction, decreases bronchial hyperresponsiveness and inhibits recruitment of other inflammatory cells into the airway epithelium. ( NCI )] (UMLS (NCI) C0886658) FPL 59002KP;
NEDOCROMIL SODIUM;
NEDOCROMIL SODIUM PREPARATION;
=Organic Chemical; Pharmacologic Substance ;
=NEDOCROMIL;
=NEDOCROMIL SODIUM 1.75 MG/ACTUAT;
NEDOCROMIL SODIUM 2 %;
|
- 5. 2(1H)-pyridinone, 4-hydroxy-1-beta-D-ribofuranosyl
- [A synthetic analogue of nucleoside uridine lacking a ring nitrogen in the 3-position. 3-deazauridine inhibits cytidine synthase, thereby reducing intracellular levels of cytidine and deoxycytidine and disrupting DNA and RNA synthesis. This agent may trigger apoptosis and enhance differentiation of neoplastic cells.. (NCI04) ( NCI )] (UMLS (NCI) C0000399) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
| - 13. 4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-
- [A pyrazinoisoquinoline derivative with anthelminthic property. Praziquantel increases the permeability of the tegument of susceptible worms, resulting in an influx and increase in intra-tegumental calcium leading to rapid contractions and paralysis of the worm's musculature through a subsequent increase in levels of calcium in the sarcoplasmic reticulum. In addition, vacuolization of the tegumental syncytium and blebbing results in tegument disintegration, leads to antigen exposure and elicit host defense responses to the worm. The result is the formation of granulomas and phagocytosis. ( NCI )] (UMLS (NCI) C0032911) =Organic Chemical; Pharmacologic Substance ;
=Anthelminthics;
2 benzazine =PRAZIQUANTEL 600 MG |
- 6. 2(1H)-Pyrimidinone, 4-amino-1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)-
- [A drug being studied for use as an anticancer agent. ( NCI )] (UMLS (NCI) C0877874) Troxacitabine;
=Organic Chemical; Pharmacologic Substance ;
| - 14. 4H-Pyrido(1,2-a)pyrimidin-4-one, 9-methyl-3-(1H-tetrazol-5-yl)-, Potassium Salt
- [The potassium salt form of pemirolast, a pyrimidinone derivative with antiallergic property. Pemirolast potassium exerts its action by blocking the antigen-mediated calcium ion influx into mast cells. This prevents mast cell degranulation, resulting in mast cell stabilization and inhibition of the release of inflammatory mediators, histamine and leukotrienes, which are involved in the allergic process. Pemirolast potassium also prevents inflammatory mediator release from eosinophils. ( NCI )] (UMLS (NCI) C0872971) Pemirolast Potassium;
PEMIROLAST POTASSIUM PREPARATION;
PEMIROLAST POTASSIUM UNIDENTIFIED =Organic Chemical; Pharmacologic Substance ;
=Pemirolast;
Unclassified Ingredients |
- 7. 2(1H)-Pyrimidinone, 4-amino-1-[4, 5-dihydroxy- 3-(hydroxymethyl)-2-cyclopenten-1-yl]-
- [A synthetic cyclopentenyl antimetabolite analogue of cytidine with antineoplastic activity and antiviral activity. Cyclopentenyl cytosine competitively inhibits cytidine triphosphate (CTP) synthase, thereby depleting cytidine pools and inhibiting DNA synthesis. This agent may also induce differentiation of some tumor cell types. Cyclopentenyl cytosine's antiviral activity is broad-spectrum. (NCI04) ( NCI )] (UMLS (NCI) C0111606) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
| - 15. 4H-Pyrrolo(3,2-d)pyrimidin-4-one,1,5-dihydro-2-amino-7-(3-pyridinylmethyl)
- [A substance that is being studied for the treatment of cancer. ( NCI )] (UMLS (NCI) C0338278) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
|
- 8. 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-,(2R-cis)-
- [A synthetic nucleoside analog of cytosine with activity against human immunodeficiency virus type 1 reverse transcriptase. Emtricitabine is phosphorylated by cellular enzymes to form emtricitabine 5'-triphosphate. Emtricitabine 5'-triphosphate inhibits the activity of the HIV-1 reverse transcriptase by competing with the natural substrate deoxycytidine 5'-triphosphate. Incorporation of emtricabine 5'-triphosphate into nascent viral DNA results in chain termination. Emtricitabine 5'-triphosphate is a weak inhibitor of mammalian DNA polymerase alpha, beta, epsilon and mitochondrial DNA polymerase gamma. ( NCI )] (UMLS (NCI) C0909839) EMTRICITABINE;
EMTRICITABINE PREPARATION;
FTC;
=Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance =[AM800] ANTIVIRALS;
Unclassified Ingredients =EMTRICITABINE 200 MG;
| - 16. 6H-Pyrido[4, 3-b]carbazolium, 9-hydroxy-2,5,11-trimethyl-acetate (salt)
- [A derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties. As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis (NCI04) ( NCI )] (UMLS (NCI) C0100593) =Organic Chemical; Pharmacologic Substance ;
|
home
