[Nuclear Receptor Co-Repressor 1, encoded by the NCOR1, mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. This protein is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined. (from LocusLink) ( NCI )] (UMLS (NCI) C1384567) hN-CoR; KIAA1047; N-CoR; NCOR1; N-CoR1; Nuclear Receptor Corepressor; Nuclear Receptor Co-Repressor 1; Thyroid Hormone- and Retinoic Acid Receptor-Associated Corepressor 1; TRAC1 =Amino Acid, Peptide, or Protein; Biologically Active Substance