- 1. EIF-3 P48
- [Eukaryotic initiation factor-3 (eIF3) is the largest of the eIFs and consists of at least ten non-identical subunits in mammals. eIF3S6 (p48) appears to interact with eIF3-p170. eIF3S6 binds to the 40S ribosome and promotes the binding of methionyl-tRNAi and mRNA. Cytoplasmic eIF3 is ubiquitously expressed. (from Swiss-Prot Q64252 and NCI) ( NCI )] (UMLS (NCI) C0294121) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 7. EIF2B2
- [This gene plays a role in the regulation of protein translation. ( NCI )] (UMLS (NCI) C1414328) EIF2B2 Gene;
Eukaryotic Translation Initiation Factor 2B, Subunit 2 Beta, 39kDa Gene =Gene or Genome |
- 2. EIF1
- [This gene is involved in DNA binding and protein synthesis. ( NCI )] (UMLS (NCI) C1414323) EIF1 Gene;
Eukaryotic Translation Initiation Factor 1 Gene =Gene or Genome | - 8. EIF2B4
- [This gene is involved in both the initiation and regulation of protein synthesis. ( NCI )] (UMLS (NCI) C1414330) EIF2B4 Gene;
Eukaryotic Translation Initiation Factor 2B, Subunit 4 Delta, 67kDa Gene =Gene or Genome |
- 3. EIF2AK1
- [Expressed by interferon-induced human PRKR Gene (GCN2 Family), 551-aa 62-kDa Interferon-Inducible elF2Alpha Kinase is a homodimeric serine/threonine protein kinase containing 2 DRBM domains that is activated by double-stranded RNA in the presence of ATP. Binding to dsRNA induces PRKR dimerization and activation, leading to autophosphorylation in the activation loop, PRKR phosphorylation of EIF2-alpha, and inhibition of protein synthesis initiation. P58(IPK) inhibition by P52(rIPK) upregulates PRKR activity. IFNG mRNA activates PRKR through a conserved 5-prime UTR pseudoknot to control its own translation yield. HCV envelope protein E2 contains a sequence identical to phosphorylation sites of PRKR and EIF2-alpha. E2 inhibits PRKR inhibitory activity on protein synthesis and cell growth, which may contribute to HCV-associated hepatocellular carcinoma. (NCI) ( NCI )] (UMLS (NCI) C0058980) =Amino Acid, Peptide, or Protein; Enzyme
| - 9. EIF2B5
- [This gene plays a role in the initiation of protein biosynthesis. ( NCI )] (UMLS (NCI) C1414331) EIF2B5 Gene;
Eukaryotic Translation Initiation Factor 2B, Subunit 5 Epsilon, 82kDa Gene =Gene or Genome |
- 4. EIF2AK1
- [This gene plays a role in the negative regulation of protein synthesis. ( NCI )] (UMLS (NCI) C1335264) EIF2AK1 Gene;
Eukaryotic Translation Initiation Factor 2-Alpha Kinase 2 Gene =Gene or Genome ;
| - 10. EIF3S6
- [This gene is involved in the initiation and regulation of protein translation. ( NCI )] (UMLS (NCI) C0812224) EIF3S6 Gene;
Eukaryotic Translation Initiation Factor 3, Subunit 6 48kDa Gene;
=Gene or Genome |
- 5. eIF2B
- [EIF2B is a heteropentameric complex (alpha, beta, gamma, delta, and epsilon subunits) essential for protein synthesis that catalyzes GDP/GTP exchange of its Eukaryotic Initiation Factor 2 substrate (restores GTP bound EIF2). For EIF2 to perform additional rounds of initiation, it must be recycled by GDP/GTP exchange. Thus, EIF2B sustains translation. EIF2B-epsilon contains a putative nucleotide-binding domain that may be involved in nucleotide exchange. EIF2B defects cause VWM. (NCI) ( NCI )] (UMLS (NCI) C0606869) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 11. EIF4E Homologous Protein
- [Eukaryotic Translation Initiation Factor 4E-Like 3, encoded by the EIF4EL3 gene, belongs to the eukaryotic initiation factor 4E family. This protein recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. EIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G. (from SWISS-Prot) ( NCI )] (UMLS (NCI) C0675677) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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- 6. EIF2B1
- [This gene is involved in the initiation of protein synthesis. ( NCI )] (UMLS (NCI) C1414327) EIF2B1 Gene;
Eukaryotic Translation Initiation Factor 2B, Subunit 1 Alpha, 26kDa Gene =Gene or Genome | |
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