- 1. DKFZP564P2063
- [Epidermal Growth Factor-Like Protein 6, encoded by the human EGFL6 gene, is a member of the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. This glycoprotein contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an Arg-Gly-Asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. (From LocusLink, Swiss-Prot and NCI) ( NCI )] (UMLS (NCI) C0911758) EGF Repeat-Containing Protein 6;
EGFL6;
EGFL6 Protein;
EGF-Like 6;
Epidermal Growth Factor Repeat Containing Protein;
Epidermal Growth Factor-Like Protein 6;
MAEG;
MAM- and EGF-Containing Protein;
MAM Domain- and EGF Domain-Containing Protein;
W80 =Amino Acid, Peptide, or Protein; Biologically Active Substance | - 2. DKFZP586I1419
- [With highest expression in kidney, heart, placenta, and lung by human TAZ Gene, 400-aa 45-kDa Transcriptional Coactivator with PDZ-Binding Motif contains a putative N-terminal 14-3-3 protein-binding motif, a central WW domain, and a C-terminal PDZ-binding motif and 2-stranded coiled-coil. The PDZ-binding domain localizes TAZ to discrete nuclear foci and is required for TAZ-stimulated gene transcription; it also mediates TAZ interaction with SLC9A3R2. Interaction with 14-3-3 appears to require TAZ phosphorylation on a specific serine residue; phosphorylation reduces TAZ transcriptional coactivation by inducing nuclear export through interaction with 14-3-3. TAZ shares 91% identity with mouse Taz and 45% identity with YAP. (NCI) ( NCI )] (UMLS (NCI) C1336798) TAZ;
Transcriptional Coactivator with PDZ-Binding Motif;
WW Domain Containing Transcription Regulator 1;
WWTR1 =Amino Acid, Peptide, or Protein; Biologically Active Substance |
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