- 1. brca 1 gene
- [This gene plays a role in cell cycle control, regulation of transcription and the maintenance of genomic stability. It is also involved in the inhibition of mammary cell growth. ( NCI )] (UMLS (CSP) C0376571) =Gene or Genome
| - 8. BRCA2
- [BRCA2 putatively functions as a tumor suppressor gene, however, its exact function has not been well characterized. The similarity of, and functional analysis of, BRCA2 and BRCA1 proteins, suggests that these proteins function in the same genetic pathway. BRCA1 and BRCA2 have transcriptional activation potential and the two proteins are associated with the activation of double-strand break repair and/or homologous recombination. The two proteins have been shown to coexist and colocalize in a biochemical complex. (from LocusLink) ( NCI )] (UMLS (NCI) C0294028) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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- 2. BRCA 1 Syndrome
- (UMLS (NCI) C1332442) Early Onset Breast Ovarian Cancer Syndrome =Disease or Syndrome ;
| - 9. BRCA3
- [This gene plays a role in tumor suppression. ( NCI )] (UMLS (NCI) C1332438) BRCA3 Gene;
Breast Cancer 3 Gene;
=Gene or Genome ;
◊ [Encoded by human BRCA3 Gene, BRCA3 Protein has an unknown function and is associated with breast cancer. (from LocusLink, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1332439) BRCA3 Protein; BRCAX Protein; Breast Cancer 3 Protein Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 3. brca 2 gene
- [A gene on chromosome 13 that normally helps to suppress cell growth. A person who inherits an altered version of the BRCA2 gene has a higher risk of getting breast, ovarian, or prostate cancer. ( NCI )] (UMLS (CSP) C0598034) =Gene or Genome ;
| - 10. BRCATA
- [This gene plays a role in tumor pathogenesis. ( NCI )] (UMLS (NCI) C1332440) BRCATA Gene;
"Breast Cancer, 11;22 Translocation Associated Gene"
; =Gene or Genome ;
◊ [The most frequently occurring constitutional reciprocal translocation in man is t(11;22)(q23;q11). The number of breast cancer cases is significantly higher than expected among the translocation carriers. The information should be useful in connection with counseling and screening. The BRCATA gene may be involved in the pathogenesis of breast cancer and is located at chromosome 11q23. (from OMIM 600048) ( NCI )] (UMLS (NCI) C1332441) Breast Cancer, 11;22 Translocation Associated Protein Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 4. BRCA 2 Syndrome
- (UMLS (NCI) C1332443) Site Specific Early Onset Breast Cancer Syndrome =Disease or Syndrome ;
| - 11. BRCD1
- [This gene plays a role in tumor suppression and is frequently associated with retinoblastoma and ductal carcinoma. ( NCI )] (UMLS (NCI) C1332444) BRCD1 Gene;
Breast Cancer, Ductal, Suppressor-1 Gene;
=Gene or Genome ;
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- 5. brca gene
- [newly discovered protooncogene; mutation is responsible for about half of the inherited cases of breast cancer; implicated in esophageal, head, and neck cancer. ( CSP )] (UMLS (CSP) C0596223) =Gene or Genome =antioncogene;
| - 12. BRCD2
- [This gene may be involved in tumor suppression. ( NCI )] (UMLS (NCI) C1332446) BRCD2 Gene;
Breast Cancer, Ductal (2) Gene;
=Gene or Genome ;
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- 6. BRCA1
- [BRCA1, which functions as a tumor suppressor in human breast cancer cells, is a nuclear phosphoprotein which associates with RNA polymerase II holoenzyme. Mutations in BRCA1 are predicted to be responsible for approximately 45% of inherited breast cancer and more than 80% of inherited breast and ovarian cancer. BRCA1 may function as a transcriptional regulator, due to an amino terminal DNA-binding ring finger motif, nuclear localization signals, and an acidic carboxy terminal domain. BRCA1 is also a granin-like protein that functions as a secreted growth inhibitory protein. BRCA1 may normally serve as a negative regulator of mammary epithelial cell growth. This function is compromised in breast cancer either by direct mutation or by alterations in gene expression. BRCA1 participates in transcription-coupled repair of oxidative DNA damage. (LocusLink) ( NCI )] (UMLS (NCI) C0259275) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 13. BRCR/FLUT
- (UMLS (NCI) C0281147) =Therapeutic or Preventive Procedure
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- 7. BRCA1 Interacting Protein C-Terminal Helicase 1 Gene
- [This gene is involved in DNA double-strand break repair. ( NCI )] (UMLS (NCI) C1426958) BRIP1;
BRIP1 Gene;
=Gene or Genome ;
| - 14. BRCR/FLUT/LEUP
- (UMLS (NCI) C0281148) =Therapeutic or Preventive Procedure
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