- 1. AGO
- [A country in Southern Africa, bordering the South Atlantic Ocean, between Namibia and Democratic Republic of the Congo. (NCI) ( NCI )] (UMLS (NCI) C0003023) =Geographic Area
| - 5. AGORAPHOBIA W PANIC DIS
- (UMLS (ICD9CM) C0236800) =Mental or Behavioral Dysfunction
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- 2. AGO Protein
- [Encoded by human FBXW7 Gene, alpha and beta AGO Protein (F-Box Family), 707 and 627 amino acids respectively, differ in their N-termini and contain the putative functional F box and seven WD repeats. F-box proteins constitute one of four SCF subunits of the ubiquitin protein ligase complex, involved in phosphorylation-dependent ubiquitination. AGO protein binds to cyclin E, and probably targets it for ubiquitin-mediated degradation. AGO mutant cells have elevated levels of cyclin E without increased cyclin E mRNA levels. Homologue of Cdc4 (S. cerevisiae) and Archipelago (Drosophila), human AGO also has low similarity to Met30p (S. cerevisiae). Drosophila and human AGO are 78% identical. AGO may represent a mutational target in ovarian cancer. (from OMIM and NCI) ( NCI )] (UMLS (NCI) C0755295) Archipelago Homologue Protein;
F-box and WD-40 domain protein 7;
F-box protein FBW7;
FBXW7;
FBXW7 Protein =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 6. AGORAPHOBIA W/O PANIC
- (UMLS (ICD9CM) C0001819) =Mental or Behavioral Dysfunction
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- 3. Agonist
- [An agent that has affinity for a receptor and intrinsic activity at that receptor. ( NCI )] (UMLS (NCI) C0243192) =Pharmacologic Substance ;
| - 7. agouti protein
- [A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in MELANOCYTES. Agouti protein antagonizes the signaling of MELANOCORTIN RECEPTORS and has wide distribution including ADIPOSE TISSUE; GONADS; and HEART. Its overexpression in agouti mice results in uniform yellow coat color, OBESITY, and metabolic defects similar to type II diabetes in humans. ( MSH )] (UMLS (CSP) C0214356) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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- 4. agoraphobia
- [intense, irrational fear of open spaces, characterized by marked fear of being alone or of being in public places where escape would be difficult or help might not be available. ( CSP )] (UMLS (CSP) C0001818) =Mental or Behavioral Dysfunction
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