Modern Anti-Aging Strategies: Clinical Trials, Technologies, and Therapeutic Interventions in Dermatology. Volume III

Description

Introduction
The global demand for aesthetic and anti-aging interventions has driven a substantial expansion of clinical research focused on wrinkles, skin laxity, photoaging, and overall skin rejuvenation. Over the past two decades, advances in medical devices, injectable biomaterials, energy-based technologies, topical formulations, dietary supplements, and regenerative approaches have reshaped both clinical practice and research priorities. This article presents a comprehensive narrative review of 42 registered clinical trials conducted between 2005 and 2025, synthesizing evidence from diverse intervention categories to illustrate how scientific support for wrinkle reduction and skin rejuvenation has evolved.
Wrinkles and visible signs of skin aging remain among the most common aesthetic concerns worldwide. These changes arise from a complex interplay of intrinsic aging processes and extrinsic factors, including ultraviolet radiation, environmental pollution, lifestyle influences, and progressive structural alterations in collagen, elastin, and subcutaneous tissues. As understanding of skin biology has advanced, clinical research has increasingly emphasized non-invasive and minimally invasive strategies that aim to improve skin appearance while reducing procedural risk and downtime.