TAF2C

[Encoded by human TAF4 Gene (TAF2C Family), 1083-aa 110-kDa nuclear TBP-Associated Factor 4, containing 1 TAFH/NHR1 domain, is one of the larger subunits of the multimeric TFIID complex that mediates promoter responses to various activators and repressors. A component of the TFTC-HAT complex, TAF4 interacts with transcription factor CREB and other proteins containing glutamine-rich regions and potentiates transcriptional activation by the AF-2S of the RAR, THR and vitamin D3 receptor. TFIID is composed of TBP and many evolutionarily conserved TAFs, which participate in basal transcription, serve as coactivators, and function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. Multimeric protein complex TFIID binds to the core promoter to position polymerase, serves as scaffold for assembly of the transcription complex, and acts as a channel for regulatory signals. (NCI) ( NCI )]

UMLS (NCI) C1336585

TAF2C1
TAF4
TAF4 RNA Polymerase II
TAF4A
TAFII130
TAFII135
TATA Box Binding Protein-Associated Factor 135 kD
TATA Box Binding Protein-Associated Factor RNA Polymerase II C1 130kD
TBP-Associated Factor 135 kD
TBP-Associated Factor 4
TBP-Associated Factor RNA Polymerase II C1 130kD
Transcription Initiation Factor TFIID 135 kDa Subunit

Amino Acid, Peptide, or Protein
Biologically Active Substance

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