[The potassium salt of oxonate, an enzyme inhibitor that modulates 5- fluorouracil (5-FU) toxicity. Oxonate (Oxo), one of the components of the antineoplastic agent S1, inhibits the enzyme orotate phosphoribosyltransferase which catalyzes the conversion of 5-FU to its active or phosphorylated form, FUMP. Upon oral administration, Oxo is selectively distributed to the intracellular sites of tissues lining the small intestines, thereby, producing localized inhibitory effects within the gastrointestinal tract. As a result, 5-FU associated gastrointestinal toxic effects are reduced and the incidence of diarrhea or mucositis is decreased with S1 therapy. ( NCI )]
UMLS (NCI) C0393003 - Organic Chemical
- Pharmacologic Substance
home 
Armenian-English 
top