[A natural naphtylisoquinoline alkaloid with antiviral properties isolated from the tropical plant Ancistrocladus korupensis. Michellamine B inhibits HIV reverse transcriptase (RT) activity and HIV-induced cellular fusion and syncytium formation, thereby inhibiting the propagation of HIV types 1 and 2. In addition, this agent inhibits human DNA polymerases alpha and beta. Michellamine B is also a noncompetitive protein kinase C inhibitor and potent antioxidant. (NCI04) ( NCI )]
UMLS (NCI) C0128431 - Organic Chemical
- Pharmacologic Substance
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