[Expressed in a cell-cycle related manner by human PML Gene (TRIM Family), nuclear phosphoprotein Tripartite Motif Protein TRIM19 is a transcription factor and tumor suppressor that regulates the p53 response to oncogenic signals, interacts with SIRT1, and contains a TRIM motif: 3 zinc-binding domains, a RING-type zinc finger, a B-box type 1 zinc finger, a B-box type 2 zinc finger, and a coiled-coil region. Extensive alternative splicing results in fourteen variations of the protein's central and C-terminal regions with an invariant N-terminus. Chromosomal translocation t(15;17)(q21;q21) involving PML and RARA is associated with acute promyelocytic leukemia. (NCI) ( NCI )]
UMLS (NCI) C0146495 - Amino Acid, Peptide, or Protein
- Biologically Active Substance
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