FYN-Associated Phosphoprotein SKAP55 Homologue

[Expressed in lung, skeletal muscle, kidney, peripheral leukocytes, spleen, brain, placenta, heart, prostate, testis, ovary, and colon by human SCAP2 Gene (SRC Kinase Family), 359-aa SRC Family Associated Phosphoprotein 2, an adaptor protein implicated in myeloid differentiation and growth arrest, is thought to play a role in SRC signal transduction pathways of tyrosine and nontyrosine kinase receptors. Like SKAP55, SKAP55R contains a PH domain, multiple tyrosine phosphorylation sites, and an SH3 domain. Unlike SKAP55, SKAP55R has an N-terminal coiled-coil domain. SKAP55R and SKAP55 are phosphorylated by FYN, but not LCK or ZAP70. Unlike SKAP55, SKAP55R is not constitutively phosphorylated in T cells. FYB in T cells binds SKAP55 and SKAP55R through their SH3 domains. (NCI) ( NCI )]

UMLS (NCI) C0755813

SAPS
SCAP2
SKAP55R
SKAP55-Related Protein
SRC Family Associated Phosphoprotein 2
SRC Kinase-Associated Phosphoprotein of 55-Related Protein
SRC-Associated Adaptor Protein

Amino Acid, Peptide, or Protein
Biologically Active Substance

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