[A synthetic cytokine and interleukin-3 (IL-3) receptor agonist with enhanced hematopoietic potency. Daniplestim exhibits 10- to 20-fold greater biological activity than recombinant human IL-3 in human hematopoietic cell proliferation and marrow colony-forming-unit assays. In contrast, this agent shows no significant increase in pro-inflammatory activity relative to native IL-3. The enhanced hematopoietic activity of daniplestim correlates with a 60-fold increase in IL-3 alpha-subunit binding affinity and 20-fold greater affinity for binding to alpha/beta receptor complexes on intact cells relative to recombinant IL-3. ( NCI )]
UMLS (NCI) C0297038 - Amino Acid, Peptide, or Protein
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