[Encoded by human CBFA2T1 Gene, conserved 604-aa 67.6-kD ETO Protein is a putative MYND zinc finger transcription factor expressed as multiple isoforms in brain, heart, lung, pituitary, skeletal muscle, pancreas, placenta, testis, and ovary. MTG8B and MTG8C variants have distinct N-termini. One frameshifted MTG8 variant lacks C-terminal zinc fingers, a P/S/T-rich domain, and a coiled-coil structure. In AML-M2, t(8;21)(q22;q22) in stem cells produces a fused chimeric RUNX1-CBFA2T1 protein. Associated with NCOR/HDAC, this protein may repress transcription and differentiation in hematopoietic precursors. p14(ARF) may be a target of AML1-ETO. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C0218234 - Amino Acid, Peptide, or Protein
- Biologically Active Substance
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