[insecticide that came into prominence during and after World War II; for a time it proved very effective, but insect populations rapidly developed tolerance for it, hence much of its original effectiveness has been lost; general usage is now widely discouraged because of the toxicity that results from the environmental persistence of this agent. ( CSP )] (UMLS (NCI) C0011041) =Organic Chemical; Hazardous or Poisonous Substance =chlorohydrocarbon insecticide;;
[A synthetic, colorless to light yellow liquid that is soluble in polar organic solvents and only slightly soluble in water. 1,2,3-Trichloropropane is used as both a chemical intermediate and cross-linking agent in the production of polymers. 1,2,3-Trichloropropane is flammable and, when heated to decomposition, emits toxic fumes of hydrogen chloride. Exposure of humans to 1,2,3-trichloropropane vapor causes irritation of the eyes and throat. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0043760) =Organic Chemical
[The hydrochloride salt form of trazodone, a synthetic triazolopyridine derivative with antidepressant and sedative properties. Based on studies from animal models, trazodone selectively inhibits the re-uptake of serotonin by synaptosomes in the brain, thereby increasing serotonin levels in the synaptic cleft and potentiating serotonin activity. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. The sedative effect of trazodone is likely via alpha-adrenergic and mild histamine H1 blocking actions. ( NCI )] (UMLS (NCI) C0282369) =Organic Chemical; Pharmacologic Substance ;; =TRAZODONE;; =TRAZODONE HYDROCHLORIDE 150 MG;;TRAZODONE HYDROCHLORIDE 300 MG;;TRAZODONE HYDROCHLORIDE 50 MG;;TRAZODONE HYDROCHLORIDE 100 MG
[An alpha-1-adrenergic antagonist that acts by blocking alpha-adrenergic receptors in the smooth muscle of blood vessels (arteries, arterioles and veins), gastrointestinal tract, and radial smooth muscle of the iris. This prevents smooth muscle contraction and results in vasodilatation. Administered in the eye, dapiprazole hydrochloride produces miosis. In the heart, it may antagonize alpha-1 adrenoreceptors in myocytes causing a mild negative inotropic effect. ( NCI )] (UMLS (NCI) C0770916) Dapiprazole Hydrochloride;;DAPIPRAZOLE HYDROCHLORIDE PREPARATION =Organic Chemical; Pharmacologic Substance =dapiprazole;; =DAPIPRAZOLE HYDROCHLORIDE 0.5 %;;
[A synthetic triepoxide alkylating agent with cytostatic and immunosuppressant properties. Anaxirone alkylates DNA via actual or derived epoxide groups, resulting in inhibition of DNA synthesis. This agent exhibits a broad spectrum of antineoplastic activity against experimental tumors, including those resistant to other alkylating agents. (NCI04) ( NCI )] (UMLS (NCI) C0043767) =Organic Chemical; Pharmacologic Substance ;;
[Purgative anthraquinone found in several plants, especially Rhamnus frangula. It was formerly used as a laxative, but is now used mainly as tool in toxicity studies. ( MSH )] (UMLS (NCI) C0013982) =Organic Chemical; Pharmacologic Substance; Biologically Active Substance =Cascara;; =alloin;;
[A drug that blocks the effects of male hormones in the body. It belongs to the family of drugs called antiandrogens. ( NCI )] (UMLS (NCI) C0068771) =Organic Chemical; Pharmacologic Substance =[AN000] ANTINEOPLASTICS;;imidazole;;[HS900] HORMONES/SYNTHETICS/MODIFIERS, OTHER;; =NILUTAMIDE 150 MG;;
[A nitrogen mustard vesicant that has application in chemical warfare, and has been used as a cytostatic alkylating agent in anti cancer therapy. ( NCI )] (UMLS (NCI) C0045236) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid ;;
[neurotoxin used to induce experimental CNS and sympathetic neural lesions that model aging and various nervous disorders; also used to induce behavioral circling and as a potential antineoplastic for neuroblastoma. ( CSP )] (UMLS (NCI) C0085196) =Organic Chemical; Pharmacologic Substance =catecholamine;;Neurotoxin;;Dopamine Antagonist;;adrenergic antagonist
[A synthetic, colorless crystalline solid that is slightly soluble in water and soluble in organic solvents. It has been used primarily in pesticide formulations and as a wood preservative, although most uses have been cancelled in the US. When heated to decomposition, 2,4,6-trichlorophenol emits toxic and corrosive fumes of hydrochloric acid and other toxic gases. Exposure of humans to 2,4,6-trichrophenol via inhalation has been reported to cause respiratory effects, altered pulmonary function and pulmonary lesions. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0045437) =Organic Chemical; Hazardous or Poisonous Substance ;;
[An anticancer drug that belongs to the family of drugs called alkylating agents. ( NCI )] (UMLS (NCI) C0019453) =Organic Chemical; Pharmacologic Substance ;; =[AN000] ANTINEOPLASTICS;;triazine =ALTRETAMINE 50 MG
[one of the thyroid hormones; an organic iodine containing compound secreted in small amounts by the thyroid gland; most circulating triiodothyroinine is produced by the deiodination of thyroxine in the peripheral tissues. ( CSP )] (UMLS (NCI) C0041014) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Hormone =Thyroid Gland Hormone;;Thyronines;;3,3',5-triiodo-L-thyronine;;[HS851] THYROID SUPPLEMENTS =3,3',5-triiodo-L-thyronine;;LIOTHYRONINE SODIUM;;
[A triclosan analogue with an antibacterial property. Triclocarban exerts its effect by inhibiting the activity of enoyl-(acyl-carrier protein) (ACP) reductase, widely distributed in bacteria, fungi and plants. ACP reductase catalyses the last step in each cycle of fatty acid elongation in the type II fatty acid synthase systems. As a result, this agent interupts cell membrane synthesis and leads to bacterial growth inhibition. ( NCI )] (UMLS (NCI) C0077072) =Organic Chemical; Pharmacologic Substance
[A derivative of cysteine with antimitotic activity and potential antineoplastic activity. (NCI04) ( NCI )] (UMLS (NCI) C0601886) =Amino Acid, Peptide, or Protein ;;
[trihydroxyisoflavone; phytoestrogen found in soy based foods; may have cancer chemoprotective activity. ( CSP )] (UMLS (NCI) C0061202) =Organic Chemical; Pharmacologic Substance; Biologically Active Substance =flavone;;
[An isoflavone from Pueraria thunbergiana, which induces differentiation and apoptosis in cancer cells. (NCI) ( NCI )] (UMLS (NCI) C0769356) Tectorigenin =Organic Chemical
[A member of the tyrphostin family of tyrosine kinase inhibitors that competitively binds and inhibits epidermal growth factor receptor and GTPase activity of transducin and induces apoptosis in human leukemic cell lines. (NCI) ( NCI )] (UMLS (NCI) C0213654) =Organic Chemical; Pharmacologic Substance
[A country in southeastern Europe and southwestern Asia (that portion of Turkey west of the Bosporus is geographically part of Europe), bordering the Black Sea, between Bulgaria and Georgia, and bordering the Aegean Sea and the Mediterranean Sea, between Greece and Syria. (NCI) ( NCI )] (UMLS (NCI) C0041400) =Geographic Area
[A tetrahydroisoquinoline alkaloid isolated from the marine tunicate Ecteinascidia turbinate. Ecteinascidin 743 (ET743) exhibits potent tumor cytotoxicity by prolonging the G2-M phase of the cell cycle. This agent interacts with the transcription-coupled nucleotide excision repair machinery to induce lethal DNA strand breaks. (NCI04) ( NCI )] (UMLS (NCI) C1311070) =Organic Chemical; Pharmacologic Substance ;;
[A malignant epithelial neoplasm characterized by the presence of a trabecular glandular architectural pattern. ( NCI )] (UMLS (NCI) C0302182) =Neoplastic Process
[A benign epithelial neoplasm characterized by the presence of a trabecular glandular architectural pattern. ( NCI )] (UMLS (NCI) C0205651) =Neoplastic Process
[trabeculum of loose fibers found at the iridocorneal angle between the anterior chamber of the eye and the venous sinus of the sclera; the aqueous humor filters through the spaces between the fibers into the sinus and passes into the bloodstream. ( CSP )] (UMLS (CSP) C0040573) =Body Part, Organ, or Organ Component ;; =sclera;;
[Any surgical procedure for treatment of glaucoma by means of puncture or reshaping of the trabecular meshwork. It includes goniotomy, trabeculectomy, and laser perforation. ( MSH )] (UMLS (ICD9CM) C0040574) =Therapeutic or Preventive Procedure ;;
[creation of a fistula between the anterior chamber of the eye and the subconjunctival space by surgical removal of a portion of the trabecular meshwork, performed to facilitate drainage of the aqueous humor in glaucoma. ( CSP )] (UMLS (CSP) C0040576) =Therapeutic or Preventive Procedure ;; =glaucoma surgery;;
[(TRAY-kee-AHS-tuh-mee toob) A 2-inch- to 3-inch-long curved metal or plastic tube placed in a surgically created opening (tracheostomy) in the windpipe to keep it open. ( NCI )] (UMLS (NCI) C0184159) =Medical Device
[cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi. ( CSP )] (UMLS (NCI) C0040578) =Body Part, Organ, or Organ Component ;; =Body System, Pulmonary;;Body Part