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S S S- S0 S1 S2 S3 S4 S5 S6 S7 S8 S9 SA SB SC SD SE SF SG SH SI SJ SK SL SM SN SO SP SQ SR SS ST SU SV SW SY
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- (+)-(4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidino-piperidino)carbonyloxy]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinol-3,14,(4H,12H)-dione
- [DNA topoisomerase I inhibitor. ( CSP )] (UMLS (NCI) C0123931) =Organic Chemical; Pharmacologic Substance ;; =[AN000] ANTINEOPLASTICS;;(+)-Camptothecin;;enzyme inhibitor;; =Irinotecan Hydrochloride
- (+)-(S)-4,4'-(1-Methyl-1,2-ethanediyl)di(2,6-piperazinedione)
- [A drug used to protect the heart from the toxic effects of anthracycline drugs such as doxorubicin. It belongs to the family of drugs called chemoprotective agents. ( NCI )] (UMLS (NCI) C0086444) =Organic Chemical; Pharmacologic Substance ;; =Razoxane;;[CV900] CARDIOVASCULAR AGENTS, OTHER =Dexrazoxane Hydrochloride;;
- (+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole
- [An imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative properties. Dexmedetomidine selectively binds to presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibit sympathetic activity, thereby leading to sedation and anxiolysis. The analgesic effect of this agent is mediated by binding to More…
- (+)-Simalikalactone D
- [A quassinoid phytochemical isolated from Simaba multiflora, Quassia africana and other plant species with potential antineoplastic activity. This agent also has antimalarial and antiviral properties. (NCI04) ( NCI )] (UMLS (NCI) C0074548) =Organic Chemical
- (+/-)-Sulforaphane
- [A naturally-occurring phytochemical belonging to the class of isothiocyanates. As the aglycone metabolite of glucosinolate glucoraphanin (sulforaphane glucosinolate), sulforaphane acts as an antioxidant and potent stimulator of endogenous detoxifying enzymes. This agent displays anticarcinogenic properties due to its ability to induce phase II detoxification enzymes, such as glutathione S-transferase and quinone reductase, thereby providing protection against certain carcinogens and More…
- (-) Strand ssRNA Virus
- [A single stranded RNA virus where the RNA strand is the complement of a mRNA. ( NCI )] (UMLS (NCI) C1093214) Negative Sense ssRNA Virus;;Negative Strand ssRNA Virus;;ssRNA Virus, (-) Strand =Virus ;;
- (-)-Salbutamol Hydrochloride
- [The hydrochloride salt form of levalbuterol, a relatively selective sympathomimetic beta2 receptor agonist with bronchodilator activity. Levalbuterol hydrochloride binds to beta2-adrenergic receptors in bronchial smooth muscle and activates intracellular adenyl cyclase, thereby increasing the production of cyclic-3', 5'-adenosine monophosphate (cAMP). Increased cAMP levels lead to the activation of protein kinase A, which inhibits the phosphorylation of myosin and lowers More…
- (15S)-15-Methylprostaglandin F(sub 2alpha) Tromethamine
- [A synthetic 15-methyl analogue of the naturally occurring prostaglandin F2alpha. Carboprost tromethamine induces myometrium smooth muscle contraction by binding to the prostaglandin F2alpha receptors. This drug can be used to induce contractions to end pregnancy or to induce labour and to control severe postpartum bleeding. Due to its contractile effects on gastrointestinal smooth muscle, carboprost tromethamine can cause vomiting and diarrhea. ( NCI )] (UMLS (NCI) C0054721) =Organic More…
- (1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-hexopyranoside
- [An anticancer drug that belongs to the family of drugs called antitumor antibiotics. Also called 4-demethoxydaunorubicin. ( NCI )] (UMLS (NCI) C0020789) =Organic Chemical; Pharmacologic Substance ;; =antineoplastic antibiotics;;(8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione =Idarubicin HCl;;
- (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione
- [An enteric-coated formulation of ixabepilone, a semisynthetic analogue of epothilone B and a non-taxane tubulin inhibitor, with antineoplastic activity. Ixabepilone binds to and stabilizes tubulin molecules, thereby interfering with the dynamics of microtubule assembly/disassembly. This results in cell cycle arrest at G2-M phase and leads to apoptosis of fast growing tumor cells. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Compared to More…
- (2S)-2-Methylbutanoic Acid, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester
- [HMG coA reductase inhibitor which inhibits cholesterol biosynthesis and thus lowers blood cholesterol levels; also blocks isoprenylation of protein CAAX motifs. ( CSP )] (UMLS (NCI) C0024027) =Organic Chemical; Pharmacologic Substance ;; =antihypercholesterolemic agent;;[CV350] ANTILIPEMIC AGENTS;;naphthalene;; =[1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl More…
- (2S)-3-(4-Hydroxyphenyl)-4-methyl-2-(4-(2-(1-piperidinyl)ethoxy)phenyl)-2H-1-benzopyran-7-ol
- (UMLS (NCI) C1611987) Acolbifene;; =Organic Chemical ;;
- (2S,3R)-3-(((1S)-2,2-Dimethyl-1-(methylcarbamoxy)propyl)carboyl)-2-hydroxy-5-methylhexanohydroxamic Acid
- [An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. Marimastat is a matrix metalloproteinase inhibitor. ( NCI )] (UMLS (NCI) C0338344) =Organic Chemical; Pharmacologic Substance
- (2S,3S)-3,4-Dimethyl-2-phenylmorpholine L-(+)-tartrate(1:1)
- [A phenylalkylamine sympathomimetic amine with appetite depressant property. Phendimetrazine tartrate is a prodrug that is hydrolyzed to the active metabolite phenmetrazine, which competes with norepinephrine and dopamine for their presynaptic transporters, thereby blocks the reuptake of these monoamines at the neuronal junctions. As a result, this prolongs activities of dopamine and norepinephrine and leads to central nervous system (CNS) stimulation and metabolic effects, including More…
- (2S,3S)-3-acetyl-1,2,3,4,6,11-hexahydro-3,5,10,12-tetrahydroxy-6,11-dioxo-1-naphthacenyl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside
- [An anthracycline antineoplastic antibiotic isolated from the bacterium Actinomadura carminata. Carubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04) ( NCI )] (UMLS (NCI) C0007308) =Organic Chemical; Antibiotic ;;
- (2S,5R,6R)-6-((R)-2-Amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid
- [semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. ( CSP )] (UMLS (NCI) C0002680) =Organic Chemical; Antibiotic ;;
- (2S-cis)-Benzoic Acid[1-[4-[3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3-naphthacenyl]ethylidene]hydrazide
- [A benzoyl-hydrazone derivative of the anthracycline antineoplastic antibiotic daunorubicin. Zorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39590&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39590&idtype=1&closed=1" closed clinical trials using More…
- (3S)-N-Hydroxy-2,2-dimethyl-4-{{4-(4-piridinyloxy)phenyl}sulfonyl}-3-thiomorpholinecarboxamide
- [An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. Prinomastat is a matrix metalloproteinase inhibitor. Also called AG3340. ( NCI )] (UMLS (NCI) C0919273) AG3340;;Pinomastat;;Prinomastat;;Prinomastat/AG 3340 =Organic Chemical; Pharmacologic Substance ;;
- (3S,3'S)-3,3'-Dihydroxy-beta,beta-carotene-4,4'-dione
- (UMLS (NCI) C0052565) =Organic Chemical; Biologically Active Substance
- (4S,4aR,5S,5aR,12aS)-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecarboxamide Mono(5-sulfosalicylate)(Salt)
- [The sulfosalicylate salt form of meclocycline, a tetracycline antibiotic with broad-spectrum antibacterial and antiprotozoal activity. Meclocycline sulfosalicylate is bacteriostatic and inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, thereby preventing the addition of amino acids to the growing peptide chain. This tetracycline is active against a wide range of gram-positive and gram-negative bacteria. ( NCI )] (UMLS (NCI) C0700494) =Organic Chemical; More…
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