[selective estrogen receptor modulator; it is agonist for bone tissue and cholesterol metabolism but antagonist in mammary and uterine tissues. ( CSP )] (UMLS (NCI) C0039286) =Organic Chemical; Pharmacologic Substance ;; =amine;;Antiestrogen;;stilbene;;selective estrogen receptor modulator;;[AN500] ANTINEOPLASTIC HORMONES;; =(Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine;;(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate;;[6-Hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone;;(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate
[The hydrochloride salt form of bromodiphenhydramine, a synthetic ethanolamine with histamine H1 antagonistic and sedative properties. Bromodiphenhydramine hydrochloride blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. This drug also prevents histamine-induced pain and itching of mucous membranes. ( NCI )] (UMLS (NCI) C0304299) =Organic Chemical; Pharmacologic Substance ;; =Bromazine;; =BROMODIPHENHYDRAMINE HYDROCHLORIDE 3.75 MG;;BROMODIPHENHYDRAMINE HYDROCHLORIDE 12.5 MG/5ML;;
[The maleate salt form of brompheniramine, an alkylamine derivative and a histamine antagonist with anticholinergic and sedative properties. Brompheniramine maleate competes with histamine for the H1 receptor. This diminishes the actions of histamine on effector cells and decreases the histamine-mediated symptoms of allergic reaction such as bronchoconstriction, vasodilation, increased capillary permeability and spasmodic contractions of gastrointestinal smooth muscle. ( NCI )] (UMLS (NCI) C0546853) =Organic Chemical; Pharmacologic Substance =BROMPHENIRAMINE;; =BROMPHENIRAMINE MALEATE 4 MG/5ML;;BROMPHENIRAMINE MALEATE 10 MG/ML;;BROMPHENIRAMINE MALEATE 12 MG;;BROMPHENIRAMINE MALEATE 6 MG;;BROMPHENIRAMINE MALEATE 2 MG/5ML;;BROMPHENIRAMINE MALEATE 4 MG;;BROMPHENIRAMINE MALEATE 2 MG;;
[A bifunctional alkylating agent and phenylalanine derivative of nitrogen mustard. Melphalan hydrochloride is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA. This agent also alkylates RNA and protein structures. As a result RNA transcription and protein synthesis are inhibited, ultimately leading to cell growth arrest and/or death. ( NCI )] (UMLS (NCI) C0771055) Melphalan Hydrochloride;;MELPHALAN HYDROCHLORIDE PREPARATION =Organic Chemical; Pharmacologic Substance =4-[bis(2-chloroethyl)amino]-L-phenylalanine;; =MELPHALAN HYDROCHLORIDE 50 MG;;
[The hydrochloride salt form of pramoxine, a morpholine derivative with local anesthetic property. Pramoxine hydrochloride decreases the permeability of the neuronal membrane to sodium ions by reversibly binding to and inhibiting voltage-gated sodium channels. This results in stabilization of the membrane and , thereby inhibiting the ionic fluxes required for membrane depolarization, hence resulting in the failure to initiate a propagated action potential and subsequent conduction blockade. ( NCI )] (UMLS (NCI) C0147008) =Organic Chemical; Pharmacologic Substance =pramocaine;; =PRAMOXINE HYDROCHLORIDE 1 %WW;;PRAMOXINE HYDROCHLORIDE 10 MG/GM;;PRAMOXINE HYDROCHLORIDE 0.1 %;;PRAMOXINE HYDROCHLORIDE 0.5 %;;PRAMOXINE HYDROCHLORIDE 1 %
[Human PIK3CB wild-type allele is located in the vicinity of 3q22.3 and is approximately 105 kb in length. This allele, which encodes phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform protein, plays a role in signaling pathways underlying the regulation of apoptosis, cell growth, and angiogenesis. ( NCI )] (UMLS (NCI) C1705590) Phosphoinositide-3-Kinase, Catalytic, Beta Polypeptide wt Allele;;PIK3C1;;PIK3CB wt Allele =Gene or Genome
[Human RPS6KB2 wild-type allele is located in the vicinity of 11q13.1 and is approximately 7 kb in length. This allele, which encodes ribosomal protein S6 kinase 2 protein, plays a role in protein synthesis via the phosphorylation of ribosomal protein 6. The RPS6KB2 gene is overexpressed in certain cancers such as adenocarcinomas of the breast and endometrium. ( NCI )] (UMLS (NCI) C1705800) p70S6Kb;;Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 wt Allele;;RPS6KB2 wt Allele;; =Gene or Genome
[Human SLC43A1 wild-type allele is located within 11p11.2-p11.1 and is approximately 31 kb in length. This allele, which encodes large neutral amino acids transporter small subunit 3 protein, plays a role in the transport of large neutral amino acids. Alterations in the gene may play a role in the development of human prostate cancer. ( NCI )] (UMLS (NCI) C1705715) POV1;;POV1 Gene;;R00504;;SLC43A1;;SLC43A1 wt Allele;;Solute Carrier Family 43, Member 1 wt Allele;; =Gene or Genome
[Pre-B-Cell Colony-Enhancing Factor, encoded by the PBEF gene, is a cytokine that acts on early B-lineage precursor cells by enhancing the effect of IL-7 and SCF on pre-B-cell colony formation. This protein is secreted and expressed in large amounts in bone marrow, liver tissue, and muscle. It is also present in heart, placenta, lung, and kidney tissues. (from LocusLink) ( NCI )] (UMLS (NCI) C0068707) =Amino Acid, Peptide, or Protein; Enzyme ;;
[Human PBEF1 wild-type allele is located in the vicinity 7q22.2 and is approximately 35 kb in length. This allele, which encodes nicotinamide phosphoribosyltransferase protein, plays a role in pre-B-cell colony formation. ( NCI )] (UMLS (NCI) C1704963) PBEF1 wt Allele;;Pre-B-Cell Colony Enhancing Factor 1 wt Allele;; =Gene or Genome
[A product of the PPBP gene, pro-platelet basic protein is processed into platelet basic protein (PBP) and connective-tissue-activating peptide III (CTAP-III). Upon platelet activation these proteins undergo further processing into beta thromboglobulin (Beta-TG) and neutrophil-activating peptide 2 (NAP2), respectively. Many of the function ascribed to CTAP-III may actually be the result of processing to NAP-2. ( NCI )] (UMLS (NCI) C1622669) Platelet Basic Protein =Amino Acid, Peptide, or Protein; Biologically Active Substance
[(per-IF-er-al) A method of replacing blood-forming cells destroyed by cancer treatment. Immature blood cells (stem cells) in the circulating blood that are similar to those in the bone marrow are given after treatment to help the bone marrow recover and continue producing healthy blood cells. Transplantation may be autologous (an individual's own blood cells saved earlier), allogeneic (blood cells donated by someone else), or syngeneic (blood cells donated by an identical twin). ( NCI )] (UMLS (NCI) C0242602) =Therapeutic or Preventive Procedure ;;
[Human SNRPF wild-type allele is located within 12q22 and is approximately 7 kb in length. This allele, which encodes small nuclear ribonucleoprotein F protein, is involved in spliceosome-mediated nuclear mRNA splicing. ( NCI )] (UMLS (NCI) C1705619) Small Nuclear Ribonucleoprotein Polypeptide F wt Allele;;SMF;;SNRPF wt Allele =Gene or Genome
[Human PBX3 wild-type allele is located within 9q33-q34 and is approximately 220 kb in length. This allele, which encodes pre-B-cell leukemia transcription factor 3 protein, is involved in transcriptional activation regulation. ( NCI )] (UMLS (NCI) C1709389) Pre-B-Cell Leukemia Transcription Factor 3 wt Allele =Gene or Genome