[A fully human, high-affinity IgG1 monoclonal antibody directed against CD20 cell surface antigen with potential antineoplastic activity. Ofatumumab binds specifically to CD20 molecule on the surface of B-cells. CD20 antigen found on over 90% of B-cell lymphomas, as well as other lymphoid tumors of B-cell origin, acts as a calcium ion channel and regulates early steps in B lymphocyte activation. Following binding, ofatumumab triggers a complement-dependent cell lysis and antibody-dependent cell-mediated cytotoxicity on B-cells overexpressing CD20, thereby depleting and preventing the proliferation of these B-cells. ( NCI )] (UMLS (NCI) C1832027) =Pharmacologic Substance ;;
[No longer participating in a study; not being followed and will not be retreated. ( NCI )] (UMLS (NCI) C1518546) Off Study;;Off-Protocol;;Off-Study;; =Qualitative Concept; ;;
[When a patient is not receiving therapy they are considered off treatment. In clinical trials, a dosing schedule may require a patient to stop medication for a period of time, then resume, such as 28 days on and 7 days off. ( NCI )] (UMLS (NCI) C1518544) =Functional Concept; ;;
[The Office for Protection from Research Risks (OPRR) is organizationally located in the Office of the Director, NIH. OPRR is charged with interpreting and overseeing implementation of the regulations regarding the Protection of Human Subjects codified at Title 45, Part 46, of the Code of Federal Regulations. Also, OPRR is responsible for providing guidance on ethical issues in biomedical and behavioral research. ( NCI )] (UMLS (NCI) C1518547) OPRR;; =Health Care Related Organization; ;;
[An employee charged with the general administrative responsibilities of any given office of a corporation or business, responsible for all paperwork, including its filing and retention over time, and the supervision of office staff. ( NCI )] (UMLS (NCI) C0402335) =Professional or Occupational Group
[The Office of Cancer Survivorship was established in 1996 to provide support and a focus for research and other activities dealing with cancer survivors. OCS workshops were held in 1996 and 1997 to define priorities for research, which included the prevalence of physical effects from cancer treatment, the prevalence of second cancers in survivors, quality of life, and quality and cost of follow-up care for survivors. ( NCI )] (UMLS (NCI) C1518552) =Health Care Related Organization
[The Office of Communications encompasses the former Office of Cancer Communications, The Office of Liaison Activities, and the Office of Cancer Information, Communication and Education. Its mission is to communicate accurate information about cancer and NCI activities to a wide array of audiences, including: cancer patients, family members, health care providers, community health educators, advocates, Congress, the media, and the general public. ( NCI )] (UMLS (NCI) C1518554) =Organization
[Formed to act as a central point of contact and NCI link to cancer advocacy organizations. Recently rolled into the Office of Communications. ( NCI )] (UMLS (NCI) C1518557) =Health Care Related Organization
[The Office of Special Populations Research was established in 1996 to advise the Director of NCI and provide a focal point for leadership and coordination on minority and other special populations research. ( NCI )] (UMLS (NCI) C1518560) OSPR;; =Organization
[ Definition:The formal name as registered in an official (government) registry, but which name might not be commonly used. Particularly used in countries with a law system based on Napoleonic law. ( HL7V3.0 )] (UMLS (HL7) C1698061) =Intellectual Product ;; =EntityNameUse;;
[The distance between a point and a fixed reference point; difference between a set point and the actual reading. ( NCI )] (UMLS (NCI) C1711330) =Quantitative Concept ;;