[A prodrug of etilefrine, an adrenergic agonist with vasoconstrictive activity. Etilefrine pivalate is hydrolyzed to etilefrine, which binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to a decrease in venous pooling and increase in blood pressure. This agent may also stimulate beta-1 adrenergic receptors leading to positive chronotropic and inotropic effects. ( NCI )] (UMLS (NCI) C0059855) More…
[The hydrochloride salt form of esmolol, a short and rapid-acting beta adrenergic antagonist belonging to the class II anti-arrhythmic drugs and devoid of intrinsic sympathomimetic activity. Esmolol hydrochloride competitively blocks beta1-adrenergic receptors in cardiac muscle and reduces the contractility and cardiac rate of heart muscle, thereby decreasing cardiac output and myocardial oxygen demands. This agent also decreases sympathetic output centrally and blocks renin secretion. More…
[The maleate salt form of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Rosiglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates More…
[The hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties. At the injection site, mepivacaine hydrochloride acts by binding to specific membrane sodium ion channels in the neuronal cell membranes, thereby inhibiting sodium influx. This leads to a blockage of nerve impulse conduction and results in a loss of sensation. ( NCI )] (UMLS (NCI) C0700542) =Organic Chemical; Pharmacologic Substance =MEPIVACAINE;; =MEPIVACAINE HYDROCHLORIDE 3 More…
[An anticancer drug that belongs to the family of drugs called antimetabolites. ( NCI )] (UMLS (NCI) C0053902) =Organic Chemical; Pharmacologic Substance ;;
[The iodide salt form of echothiophate, a long-acting cholinesterase inhibitor with parasympathomimetic activity. Echothiophate iodide potentiates the action of endogenous acetylcholine by inhibiting acetylcholinesterase that hydrolyzes acetylcholine. When applied topically to the eye, this agent prolongs stimulation of the parasympathetic receptors at the neuromuscular junctions of the longitudinal muscle of the ciliary body. Contraction of longitudinal muscle pulls on the scleral spur, More…
[An acylated sulfhydryl-containing derivative of glycine with reducing and complexing properties. Tiopronin breaks the disulphide bond of cystine and binds the sulfhydryl group of the resultant cysteine monomers to form a soluble tiopronin-cysteine-mixed disulfide, which is more water-soluble than cystine and is readily excreted. This leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation. ( NCI )] (UMLS (NCI) C0025405) =Amino Acid, More…
[A radiopharmaceutical containing methylene diphosphonate (medronate; MDP) complexed with the gamma-emitting radionuclide technetium Tc 99m with potential bone imaging activity. Upon intravenous administration, skeletal uptake of Tc 99m MDP occurs as a function of skeletal blood flow and is related to osteogenic activity. The medronate moiety of this agent has affinity for hydroxyapatite crystals in bone with abnormal accumulation at sites with increased osteoid mineralization. Labeling More…
[A radioconjugate comprised of the small peptide apcitide labeled with the gamma-emitting technetium TC99m (metastable Tc-99). Apcitide binds to platelet glycoprotein (GP) GPIIb/IIIa receptors on the surface of activated platelets. Labeling apcitide with TC99m allows localization of thrombus formation by gamma-ray imaging equipment and the ability to distinguish between old, inactive thrombi and new, active thrombi. ( NCI )] (UMLS (NCI) C0766234) A9504;;Technetium Tc-99m Apcitide;; More…
[A modified form of asparaginase, an anticancer drug that belongs to the family of drugs derived from enzymes. ( NCI )] (UMLS (NCI) C0071568) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Enzyme =[AN000] ANTINEOPLASTICS;;ASPARAGINASE;;Glycol, polyethylene;;(Monomethoxypolyethylene Glycol Succinimidyl)74-L-Asparaginase =(Monomethoxypolyethylene Glycol Succinimidyl)74-L-Asparaginase;;PEGASPARGASE 750 UNT/ML;;
[Quotient of the mass of a component and the total mass of the system containing the component. For clinical chemistry the term component is recommended, IS0 uses substance. For clinical chemistry the term system is recommended, IS0 uses mixture. ( NCI )] (UMLS (HL7) C1264663) Mass Fraction;; =Quantitative Concept =Kind of quantity;;