[A radiopharmaceutical containing the radioisotope I-123 with diagnostic property. After absorption, the iodide is distributed through the extracellular fluid of the body and accumulates in the thyroid gland, thereby allowing measurement of thyroid function. ( NCI )] (UMLS (NCI) C0304977) =Indicator, Reagent, or Diagnostic Aid; Inorganic Chemical ;; =IODIDE (AS SODIUM IODIDE);;[DX202] NON-IMAGING AGENTS RADIOPHARMACEUTICALS =Sodium iodide I123 1 MIL;;Sodium iodide I123 0.2 MIL;;SODIUM IODIDE,I-123 100 MIC;;
[A radiopharmaceutical containing the beta- and gamma-emitting radioisotope I-131. After absorption, the iodide is distributed through the extracellular fluid of the body and accumulates in the thyroid gland, thereby allowing the imaging of the thyroid. ( NCI )] (UMLS (NCI) C0304982) =Indicator, Reagent, or Diagnostic Aid; Inorganic Chemical ;; =IODIDE (AS SODIUM IODIDE);;[DX201] IMAGING AGENTS (IN VIVO) RADIOPHARMACEUTICALS =Sodium iodide I131 0.067 MIL/ML;;Sodium iodide I131 100 MIC;;Sodium iodide I131 15 MIL;;Sodium iodide I131 1 MIL;;Sodium iodide I131 2 MIL/ML;;Sodium iodide I131 50 MIL;;Sodium iodide I131 7.05 MIL;;SODIUM IODIDE,I-131 8-100 MIC
[Phenethyl isothiocyanate. A naturally occurring compound found in some cruciferous vegetables. It is being studied as an agent to prevent cancer. ( NCI )] (UMLS (NCI) C0070558) =Organic Chemical; Pharmacologic Substance; Biologically Active Substance
[The hydrochloride salt form of betaxolol, a beta-1-selective adrenergic receptor antagonist without intrinsic sympathomimetic activity. Betaxolol hydrochloride acts on the heart and circulatory system and decreases cardiac contractility and rate, thereby reducing cardiac output. When applied topically in the eye, it lowers intraocular pressure by reducing aqueous humor secretion. ( NCI )] (UMLS (NCI) C0543470) =Organic Chemical; Pharmacologic Substance =1-(4-(2-Cyclopropylmethoxy)ethyl)phenoxy)-3-))1-methylethyl)amino)-2-propanol;; =BETAXOLOL HYDROCHLORIDE 0.25 %;;BETAXOLOL HYDROCHLORIDE 0.5 %;;BETAXOLOL HYDROCHLORIDE 10 MG;;BETAXOLOL HYDROCHLORIDE 20 MG;;
[A hydralazine and monoamine oxidase (MAO) inhibitor with antidepressant activity. Isocarboxazid blocks the breakdown (oxidative deamination) of biogenic amines by inhibiting MAO, thereby increasing the concentrations of norepinephrine and 5-hydroxytrytamine (5-HT) at central aminergic receptors. These neurotransmitters are involved in sustaining mood and emotions. The down-regulation of central beta-adrenergic and serotonergic receptors by chronic inhibition of MAO may also contribute to the antidepressant effects seen by isocarboxazid. (NCI05) ( NCI )] (UMLS (NCI) C0022154) =Organic Chemical; Pharmacologic Substance ;; =isoxazole;;[CN602] MONOAMINE OXIDASE INHIBITOR ANTIDEPRESSANTS =ISOCARBOXAZID 10 MG;;
[An anticancer drug that works by inhibiting a cancer cell growth factor. Also called SU101. ( NCI )] (UMLS (NCI) C0063041) =Organic Chemical; Pharmacologic Substance ;; =isoxazole;;[MS109] ANTIRHEUMATICS, OTHER =LEFLUNOMIDE 10 MG;;LEFLUNOMIDE 20 MG;;LEFLUNOMIDE 100 MG
[A 17-ketosteroid which excreted in the urine as a metabolite of steroid hormones. The most common form of etiocholanolone present in the urine is the sulfate salt. This agent, also known as 5-isoandrosterone, may be used to evaluate adrenal cortex function, bone marrow performance and, in neoplastic disease, for immunostimulation. (NCI04) ( NCI )] (UMLS (NCI) C0015124) =Steroid; Hormone ;;
[endogenous DNA sequences able to be excised from one place and inserted at another place in the genome (transposons), or exogenous, usually viral sequences able to be inserted regardless of complementarity to endogenous genes. ( CSP )] (UMLS (CSP) C0178868) =Gene or Genome ;; =gene;;
[An addendum (source) to an existing service object (target), containing supplemental information. The addendum is itself an original service object linked to the supplemented service object. The supplemented service object remains in place and its content and status are unaltered. ( HL7V3.0 )] (UMLS (HL7) C1550540) =Idea or Concept =is sequel;;
[This relationship indicates the source Role is available to the target Role as a backup. An entity in a backup role will be available as a substitute or replacement in the event that the entity assigned the role is unavailable. In medical roles where it is critical that the function be performed and there is a possibility that the individual assigned may be ill or otherwise indisposed, another individual is assigned to cover for the individual originally assigned the role. A backup may be required to be identified, but unless the backup is actually used, he/she would not assume the assigned entity role. ( HL7V3.0 )] (UMLS (HL7) C1552560) =Idea or Concept ;; =RoleLinkType;;
[Associates a derived Act with its input parameters. E.G., an anion-gap observation can be associated as being derived from given sodium-, (potassium-,), chloride-, and bicarbonate-observations. The narrative content (Act.text) of a source act is wholly machine-derived from the collection of target acts. ( HL7V3.0 )] (UMLS (HL7) C1550535) =Idea or Concept =has pertinent information;;
[An assertion that a new observation was assumed to be the cause for another existing observation. The assumption is attributed to the same actor who asserts the observation. This is stronger and more specific than the support link. For example, a growth of Staphylococcus aureus may be considered the cause of an abscess. The source (cause) is typically an observation, but may be any service, while the target must be an observation. ( HL7V3.0 )] (UMLS (HL7) C1562189) =Idea or Concept =has pertinent information;;
[An assertion that a new observation may be the manifestation of another existing observation or action. This assumption is attributed to the same actor who asserts the manifestation. This is stronger and more specific than an inverted support link. For example, an agitated appearance can be asserted to be the manifestation (effect) of a known hyperthyroxia. This expresses that one might not have realized a symptom if it would not be a common manifestation of a known condition. The target (cause) may be any service, while the source (manifestation) must be an observation. ( HL7V3.0 )] (UMLS (HL7) C1562064) =Idea or Concept =has pertinent information;;
[The source act is a single occurrence of a repeatable target act. The source and target act can be in any mood on the "completion track" but the source act must be as far as or further along the track than the target act (i.e., the occurrence of an intent can be an event but not vice versa). ( HL7V3.0 )] (UMLS (HL7) C1554210) occurrence;; =Idea or Concept =fulfills;;
[An act relationship indicating that the source act follows the target act. The source act should in principle represent the same kind of act as the target. Source and target need not have the same mood code (mood will often differ). The target of a sequel is called antecedent. Examples for sequel relationships are: revision, transformation, derivation from a prototype (as a specialization is a derivation of a generalization), followup, realization, instantiation. ( HL7V3.0 )] (UMLS (HL7) C1550538) =Idea or Concept =ActRelationshipType;; =documents;;replaces;;is appendage;;updates (condition);;instantiates (master);;fulfills;;matches (trigger);;evaluates (goal);;has option;;has generalization;;Excerpts;;episodeLink;;transformation;;reverses;;
[A relationship of specialization that states that a concept is a particular kind of another concept. This relationship relates concepts through logical hierarchy and forms the foundation of a taxonomy. ( NCI )] (UMLS (NCI) C1705423) Is-A;;isa Relationship;;Parent-Child Relationship =Idea or Concept
[A water-in-oil emulsion that stimulates the T-cell immune response to antigens and may be used in various types of cancer vaccines. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42976&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42976&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1573" NCI Thesaurus) ( PDQ )] (UMLS (NCI) C1311732) Montanide ISA 51;;Montanide ISA-51 =Organic Chemical; Pharmacologic Substance ;;
[A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)(MSH)] (UMLS (NDFRT)) (C0242287) =Disease or Syndrome =muscle disorder;;DISORDERS OF THE PERIPHERAL NERVOUS SYSTEM
[A water-soluble triazole prodrug with broad-spectrum antifungal activity. Isavuconazole is absorbed easily, given either orally or intravenously, and hydrolyzed to its active moiety BAL4815 by plasma esterases. BAL4815 inhibits fungal cytochrome P450 lanosterol 14-alpha-demethylase (CYP51) that catalyzes the conversion of lanosterol to ergosterol, an important component of the fungal cell membrane. Enzyme inhibition by this agent leads to a decrease in ergosterol pool that distresses synthesis of fungal cell membrane, thereby increases cell membrane permeability, and promotes loss of essential intracellular elements. This ultimately causes fungal cell lysis and death. ( NCI )] (UMLS (NCI) C1832021) =Organic Chemical; Pharmacologic Substance
[blood deficiency in an organ or tissue caused by a constriction or obstruction of its blood vessels. ( CSP )] (UMLS (CSP) C0022116) =Disease or Syndrome =blood vessel disorder;; =Disease, ischemic heart;;cerebral ischemia/hypoxia;;ischemic preconditioning;;liver ischemia/hypoxia;;lung ischemia/hypoxia;;renal ischemia/hypoxia;;Brain Ischemia;;COMPARTMENT SYNDROME NOS;;Reperfusion Injury;;Disease, ischemic heart;;Ischemic optic neuropathy;;Colitis, Ischemic;;Spinal Cord Ischemia;;
[Ischemic injury to the OPTIC NERVE which usually affects the OPTIC DISK (optic neuropathy, anterior ischemic) and less frequently the retrobulbar portion of the nerve (optic neuropathy, posterior ischemic). The injury results from occlusion of arterial blood supply which may result from TEMPORAL ARTERITIS; ATHEROSCLEROSIS; COLLAGEN DISEASES; EMBOLISM; DIABETES MELLITUS; and other conditions. The disease primarily occurs in the sixth decade or later and presents with the sudden onset of painless and usually severe monocular visual loss. Anterior ischemic optic neuropathy also features optic disk edema with microhemorrhages. The optic disk appears normal in posterior ischemic optic neuropathy. (Glaser, Neuro-Ophthalmology, 2nd ed, p135) ( MSH )] (UMLS (ICD9CM) C0155305) =Disease or Syndrome =ischemia;;Optic Nerve Diseases
[process by which tissue is rendered resistant to the deleterious effects of prolonged ischemia and reperfusion by prior exposure to brief, transient period(s) of ischemia. ( CSP )] (UMLS (CSP) C0376466) =Therapeutic or Preventive Procedure =ischemia;;
[A classification of subtypes of ischemic stroke based on clinical features and the results of ancillary diagnostic studies.The TOAST classification denotes five subtypes of ischemic stroke: 1) large-artery atherosclerosis, 2) cardioembolism, 3) small-vessel occlusion, 4) stroke of other determined etiology, and 5) stroke of undetermined etiology. ( NCI )] (UMLS (NCI) C1710306) TOAST;;TOAST Classification;;Trial of ORG 10172 in Acute Stroke Treatment Classification;; =Classification
[A substance that is being studied as a treatment for oral mucositis (painful mouth sores) caused by cancer therapy. It belongs to the family of drugs called synthetic protegrin analogs. ( NCI )] (UMLS (NCI) C1134510) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;;
[Human STAT2 wild-type allele is located within 12q12-12q14 and is approximately 18 kb in length. This allele, which encodes signal transducer and activator of transcription 2 protein, is involved in interferon signaling. ( NCI )] (UMLS (NCI) C1705884) ISGF-3;;P113;;Signal Transducer and Activator of Transcription 2, 113kDa wt Allele;;STAT113;;STAT2 wt Allele;; =Gene or Genome
[Human STAT1 wild-type allele is located within 2q32.2-q32.3 and is approximately 45 kb in length. This allele, which encodes signal transducer and activator of transcription 1-alpha/beta protein, plays a role in cellular viability and transcriptional modulation of both cytokine and growth factor responsive genes. ( NCI )] (UMLS (NCI) C1705883) Signal Transducer and Activator of Transcription 1, 91kDa wt Allele;;STAT1 wt Allele;;STAT91;; =Gene or Genome
[A substance that is being studied in the treatment of cancer. ( NCI )] (UMLS (NCI) C0879385) ISIS-2503;; =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;;
[A substance that is being studied in the treatment of cancer. ( NCI )] (UMLS (NCI) C0666551) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;;
[A substance that is being studied in the treatment of cancer. ( NCI )] (UMLS (NCI) C0389883) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
[A monotheistic religion promulgated by the Prophet Mohammed with Allah as the deity. ( MSH )] (UMLS (HL7) C0022126) =Idea or Concept =religion;;Religious Affiliation
[An inherited autosomal recessive syndrome characterized by the disorganized formation of new islets in the PANCREAS and PERSISTENT HYPERINSULINEMIA HYPOGLYCEMIA OF INFANCY. It is due to focal hyperplasia of pancreatic ISLET CELLS budding off from the ductal structures and forming new islets of Langerhans. Mutations in the islet cells involve the potassium channel gene KCNJ11 or the ATP-binding cassette transporter gene ABCC8, both on CHROMOSOME 11. ( MSH )] (UMLS (NCI) C0027773) =Disease or Syndrome ;;
[A usually malignant pancreatic endocrine neoplasm, characterised by inappropriate secretion of gastrin. It is associated with Zollinger Ellison syndrome. The latter is characterised by the presence of peptic ulcer, gastroesophageal reflux disease, abdominal pain, diarrhea, and malabsorption. — 2005 ( NCI )] (UMLS (NCI) C1368066) Pancreatic Gastrin Producing Neoplasm;;Pancreatic Gastrin Producing Tumor;;Pancreatic Gastrinoma;;Pancreatic G-Cell Tumor =Neoplastic Process
[An uncommon benign or malignant neoplasm, arising from the islet cells of the pancreas. Based on the clinical manifestations, it is classified as functioning or non-functioning. ( NCI )] (UMLS (NCI) C0242363) =Neoplastic Process ;;
[transferring pancreatic islet cells within an individual or between individuals of the same or different species. ( CSP )] (UMLS (NCI) C0079646) =Therapeutic or Preventive Procedure ;; =pancreas grafting;;
[The nomenclature relates primarily to vital signs monitoring, but also includes semantics of other medical devices that are commonly used in acute care settings. There are multiple coding partitions each of which has a systematic name consisting of a set of base concepts and differentiating criteria. ( HL7V3.0 )] (UMLS (HL7) C1553860) =Intellectual Product =CodeSystem;;