[A natural toxic furan isolated from a fungus-infected sweet potato (Ipomoea batatas) with potential antineoplastic activity. Ipomeanol is activated by mixed function oxidases in vivo to its epoxide form, an alkylating agent that covalently binds cell macromolecules. This agent causes cell death by a p53-independent mechanism. (NCI04) ( NCI )] (UMLS (NCI) C0048420) =Organic Chemical; Biologically Active Substance
[An azetidinone derivative and a cholesterol absorption inhibitor with lipid-lowering activity. Ezetimibe appears to interact physically with cholesterol transporters at the brush border of the small intestine and inhibits the intestinal absorption of cholesterol and related phytosterols. As a result, ezetimibe causes a decrease in the level of blood cholesterol or an increase in the clearance of cholesterol from the bloodstream. Overall, the following effects observed are a reduction of More…
[A synthetic, colorless gas that is insoluble in water and soluble in organic solvents. It is used primarily in the production of polyvinyl fluoride and other fluoropolymers. Vinyl fluoride is extremely flammable and emits highly toxic hydrogen fluoride gas when burned. Vinyl fluoride metabolites form covalent DNA adducts that attribute to inhibition of DNA replication and to mutagenicity consequences. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) More…
[A 10% v/v solution in water of formalin( a 37% solution of formaldehyde and water). Used for tissue preservation. ( HL7V3.0 )] (UMLS (HL7) C1561470) =Intellectual Product =MaterialEntityAdditive;;
[A fragment of fibroblast growth factor-5 (FGF-5). Originally isolated from a renal cell carcinoma cell line that overexpressed FGF-5, FGF-5:117-126 peptide is recognized by tumor infiltrating cytotoxic T lymphocytes. Overexpressed by several cancer cell types, this peptide is being tested as a potential target for antineoplastic immunotherapies. (NCI04) ( NCI )] (UMLS (NCI) C1520304) Fibroblast Growth Factor-5 (117-126) Peptide;; =Amino Acid, Peptide, or Protein; Pharmacologic More…
[The 14-3-3 family of proteins mediates signal transduction by binding to phosphoserine-containing proteins. Two different binding motifs, RSXpSXP and RXY/FXpSXP, are present in nearly all known 14-3-3 binding proteins. The14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs, implicating bidentate association as a signaling mechanism with molecules such as Raf, BAD, and Cbl. (from OMIM) ( NCI )] (UMLS (NCI) C1337047) =Amino Acid, Peptide, or More…