[This gene plays a role in the regulation of cell growth and proliferation. ( NCI )] (UMLS (NCI) C0812303) FYN Gene;;FYN Oncogene Related to SRC, FGR, YES Gene =Gene or Genome
[Human FYN wild-type allele is located within 6q21 and is approximately 212 kb in length. This allele, which encodes proto-oncogene tyrosine-protein kinase Fyn protein, is involved in protocadherin signaling and regulation of T-cell signaling. ( NCI )] (UMLS (NCI) C1708031) FYN wt Allele;;SRC/YES-Related Novel Gene;;SRC/YES-Related Oncogene Homolog;;SYN;; =Gene or Genome
[Expressed in lung, skeletal muscle, kidney, peripheral leukocytes, spleen, brain, placenta, heart, prostate, testis, ovary, and colon by human SCAP2 Gene (SRC Kinase Family), 359-aa SRC Family Associated Phosphoprotein 2, an adaptor protein implicated in myeloid differentiation and growth arrest, is thought to play a role in SRC signal transduction pathways of tyrosine and nontyrosine kinase receptors. Like SKAP55, SKAP55R contains a PH domain, multiple tyrosine phosphorylation sites, and an SH3 domain. Unlike SKAP55, SKAP55R has an N-terminal coiled-coil domain. SKAP55R and SKAP55 are phosphorylated by FYN, but not LCK or ZAP70. Unlike SKAP55, SKAP55R is not constitutively phosphorylated in T cells. FYB in T cells binds SKAP55 and SKAP55R through their SH3 domains. (NCI) ( NCI )] (UMLS (NCI) C0755813) SAPS;;SCAP2;;SKAP55R;;SKAP55-Related Protein;;SRC Family Associated Phosphoprotein 2;;SRC Kinase-Associated Phosphoprotein of 55-Related Protein;;SRC-Associated Adaptor Protein;; =Amino Acid, Peptide, or Protein; Biologically Active Substance
[Encoded by human FRK Gene (SRC Family), 505-aa 58-kDa FYN-Related Kinase (tyrosine kinase) contains a putative ATP-binding motif, tyrosine kinase motifs, and SH2 and SH3 domains. FRK lacks a myristylation signal, has autophosphorylation activity, is C-terminal tyrosine phosphorylated by CSK, and may function during G1/S and suppress growth. (NCI) ( NCI )] (UMLS (NCI) C1384553) GTK;;GTK Homolog;;Nuclear Tyrosine Protein Kinase RAK;;RAK;;Tyrosine-Protein Kinase FRK =Amino Acid, Peptide, or Protein; Enzyme