 | Medical glossary. |
| selected terms: 16,054 | page 1 of 803 |
- (+)-1-Beta-D-arabinofuranosyl-5-[(E)-2-bromovi- ny1] uracil
- [A synthetic thymidine analogue with potent antiviral activity against herpes simplex and varicella zoster viruses. Sorivudine is phosphorylated into triphosphate form within the cells and this metabolite interferes with viral DNA replication by inhibiting DNA polymerase activity without been incorporated into elongating viral DNA. Due to the dangerous effects of drug-drug interactions via its metabolite, sorivudine has been removed from the market. ( NCI )] (UMLS (NCI) C0207628) More…
- (+)-Biotin
- [water-soluble, enzyme cofactor present in minute amounts in every living cell; occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. ( CSP )] (UMLS (NCI) C0005575) =Organic Chemical; Pharmacologic Substance; Vitamin
- (-)-Bactobolin
- [A 3-dichloromethylactinobolin antineoplastic antibiotic isolated from various Pseudomonas bacterial species. BN-183 induces apoptosis via a caspase-dependent pathway. This agent also has immunomodulatory properties. (NCI04) ( NCI )] (UMLS (NCI) C0052913) =Organic Chemical; Antibiotic
- (1,1'-Biphenyl)-2-carboxylic Acid, 4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-
- [A benzimidazole derivative and a non-peptide angiotensin II receptor antagonist with antihypertensive property. Telmisartan selectively antagonizes angiotensin II binding to the AT1 subtype receptor, located in vascular smooth muscle and adrenal gland. The antagonism results in vasodilation and inhibits the angiotensin II-mediated aldosterone production, which in turn leading to a decrease in sodium and water as well as an increase in potassium excretion leading to a subsequent More…
- (1,1'-Biphenyl)-3-carboxylic Acid, 2',4'-difluoro-4-hydroxy-
- [A difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. Diflunisal competitively inhibits both cyclooxygenase (COX) -1 and -2, with higher affinity for COX-1, and subsequently blocks the conversion of arachidonic acid to prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever. Diflunisal differs from other More…
- (11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
- [main glucocorticoid secreted by the adrenal cortex; its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. ( CSP )] (UMLS (NCI) C0020268) =Steroid; Pharmacologic Substance; Hormone =[HS051] GLUCOCORTICOIDS;;Pregnenediones;;[DE200] ANTI-INFLAMMATORY, TOPICAL;;[RS100] ANTI-INFLAMMATORIES, RECTAL;;[RS202] HEMORRHOIDAL PREPARATIONS WITH More…
- (11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
- [synthetic glucocorticoid with the general properties of the corticosteroids. ( CSP )] (UMLS (NCI) C0032950) =Steroid; Pharmacologic Substance ;; =[HS051] GLUCOCORTICOIDS;;Pregnadienetriols;;corticosteroid analog;; =(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione;;Prednicarbate;;PREDNISOLONE ACETATE;;Prednisolone Tebutate;;PREDNISOLONE SODIUM PHOSPHATE;;PREDNISOLONE ACETATE;;Prednisolone Tebutate;;PREDNISOLONE SODIUM PHOSPHATE;;PREDNISOLONE POWDER More…
- (11beta)-11,21-Dihydroxypregn-4-ene-3,20-dione
- [adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. ( CSP )] (UMLS (NCI) C0010124) =Steroid; Pharmacologic Substance; Hormone =[HS051] GLUCOCORTICOIDS;;
- (11beta)-21-(3-Carboxy-1-oxopropyl)-11,17-dihydroxypregn-4-ene-3,20-dione, Monosodium Salt
- [The sodium salt of hydrocortisone succinate with glucocorticoid property. Hydrocortisone sodium succinate is chemically similar to the endogenous hormone that stimulates anti-inflammatory and immunosuppressive activities, in addition to exhibit minor mineralocorticoid effects. This agent binds to intracellular glucocorticoid receptors and is translocated into the nucleus, where it initiates the transcription of glucocorticoid-responsive genes such as various cytokines and lipocortins. More…
- (11beta,16alpha)-21-(3,3-Dimethyl-1-oxobutoxy)-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))pregna-1,4-diene-3,20-dione
- [The hexacetonide salt form of triamcinolone, a synthetic glucocorticosteroid with immunosuppressive and anti-inflammatory activity. Triamcinolone hexacetonide binds to specific cytosolic glucocorticoid receptors and subsequently interacts with glucocorticoid receptor response element on DNA and alters gene expression. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Consequently, an More…
- (11beta,16alpha)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione
- [The furoate salt form of mometasone, a synthetic topical glucocorticosteroid receptor agonist with anti-inflammatory, anti-pruritic and vasoconstrictive properties. Mometasone furoate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators.. Specifically, mometasone More…
- (11beta,16alpha)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
- [synthetic glucocorticoid used in replacement therapy for adrenal insufficiency and as an anti-inflammatory and immunosuppressant in a variety of disorders. ( CSP )] (UMLS (NCI) C0040864) =Steroid; Pharmacologic Substance ;; =[HS051] GLUCOCORTICOIDS;;Pregnadienes;;Steroids, Fluorinated;;corticosteroid analog =9-alpha-Fluoro-11-beta,21-dihydroxy-16-alpha-isopropylidenedioxy-1,4-pregnadiene,3,20-dione;;TRIAMCINOLONE More…
- (11Beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
- [anti-inflammatory 9-fluoro-glucocorticoid. ( CSP )] (UMLS (NCI) C0011777) =Steroid; Pharmacologic Substance ;; =[HS051] GLUCOCORTICOIDS;;Pregnadienetriols;;Steroids, Fluorinated;;corticosteroid analog;;[DE200] ANTI-INFLAMMATORY, TOPICAL;;[OP300] ANTI-INFLAMMATORIES, TOPICAL OPHTHALMIC =9-Fluoro-11-beta,21-dihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione;;Dexamethasone acetate;;DEXAMETHASONE SODIUM PHOSPHATE;;Dexamethasone acetate;;DEXAMETHASONE SODIUM PHOSPHATE;;Dexamethasone More…
- (11beta,16alpha,17beta)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one
- [A derivative of prednisolone, a synthetic glucocorticoid with anti-inflammatory and immunosuppressive property. Upon binding to the cytosolic glucocorticoid receptor and cell entry, rimexolone activates specific glucocorticoid response elements, resulting in altered gene expression. These include induction of synthesis of anti-inflammatory protein IkappaB-alpha and inhibition of synthesis of nuclear factor kappaB (NFkappa B). As a result, pro-inflammatory cytokine production such as More…
- (11beta,16beta)-9-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione
- [A drug being studied in the treatment of graft-versus-host disease. It belongs to a family of drugs called corticosteroids. ( NCI )] (UMLS (NCI) C0004905) =Steroid; Pharmacologic Substance; Hormone
- (11beta,16beta)-9-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione Dipropionate
- [The dipropionate salt of a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, beclomethasone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. ( NCI )] (UMLS (NCI) C0004906) =Steroid; Pharmacologic Substance ;;
- (11Beta,17beta)-9-fluoro-11,17-dihydroxy-17-methylandrost-4-en-3-one
- [A halogenated derivative of 17-alpha-methyltestosterone. Similar to testosterone, fluoxymesterone binds to and activates specific nuclear receptors, resulting in an increase in protein anabolism, a decrease in amino acid catabolism, and retention of nitrogen, potassium, and phosphorus. This agent also may competitively inhibit prolactin receptors and estrogen receptors, thereby inhibiting the growth of hormone-dependent tumor lines. Fluoxymesterone is approximately five times more More…
- (11beta-21-[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutoxy]-11,17-dihydroxypregna-1,4-diene-3,20-dione
- [Ester of CHLORAMBUCIL and PREDNISOLONE used as a combination alkylating agent and synthetic steroid to treat various leukemias and other neoplasms. It causes gastrointestinal and bone marrow toxicity. ( MSH )] (UMLS (NCI) C0032949) =Steroid; Pharmacologic Substance ;;
- (17beta)-17-(1-Oxopropoxy)androst-4-en-3-one
- [A short acting oil-based injectable formulation of testosterone. Testosterone inhibits gonadotropin secretion from the pituitary gland and ablates estrogen production in the ovaries, thereby decreasing endogenous estrogen levels. In addition, this agent promotes the maintenance of male sex characteristics and is indicated for testosterone replacement in hypogonadal males. (NCI04) ( NCI )] (UMLS (NCI) C0039607) =Steroid; Pharmacologic Substance; Hormone More…
- (17Beta)-17-hydroxy-17-methylandrost-4-en-3-one
- [A methylated synthetic androgen receptor agonist with anabolic effects. Methyltestosterone, mimicking testosterone, binds to cytosolic androgen receptors, and the subsequent nuclear transfer of the ligand-receptor complex induces transcription initiation of androgen responsive genes. The gene products are responsible for normal growth and development of male sex organs and secondary sex characteristics. The agent also causes retention of nitrogen, sodium, potassium, phosphorus, as well More…
| UMLS | MEDINDEX.AM |
 to main page | About • Semantic Types • Library • Feedback |  top of page |