- 501. 1,4 Diethylene Ether
- [A synthetic, volatile, colorless liquid that is miscible with water, most organic solvents, aromatic hydrocarbons and oils. It is used primarily as a stabilizer in chlorinated solvents. 1,4-Dioxane is also used as a solvent for numerous commercial products and as a wetting/dispersing agent in textile processing. In research, it is used in certain biological procedures such as liquid scintillation counting and the preparation of histological sections for microscopic examination. The primary routes of potential human exposure to 1,4-dioxane are inhalation, ingestion and dermal contact. Acute exposure to low levels of 1,4-dioxane vapors causes eye and nose irritation. Exposure to very high levels of these vapors can result in liver and kidney damage and death. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0044018) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid ;
| - 551. 1-(3-Furanyl)-4-hydroxy-1-pentanone
- [A natural toxic furan isolated from a fungus-infected sweet potato (Ipomoea batatas) with potential antineoplastic activity. Ipomeanol is activated by mixed function oxidases in vivo to its epoxide form, an alkylating agent that covalently binds cell macromolecules. This agent causes cell death by a p53-independent mechanism. (NCI04) ( NCI )] (UMLS (NCI) C0048420) =Organic Chemical; Biologically Active Substance
|
- 502. 1,4,5,6,7,7-Hexachloro-5-norbornene-2,3-dicarboxylic Acid
- [A white, crystalline carcinogenic chlorinated hydrocarbon that emits toxic fumes of hydrochloric acid and other chlorinated compounds when heated to decomposition. Chlorendic acid is used as a reactive flame retardant, chemical intermediate, hardening agent and as an extreme pressure lubricant. Exposure to chlorendic acid causes skin, eye and respiratory tract irritation. Chlorendic acid is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05) ( NCI )] (UMLS (NCI) C0082003) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 552. 1-(3-Mercaptopropionic acid)-8-D-arginine Vasopression Monoacetate
- [An analogue of the hormone vasopressin with antidiuretic and antihemorrhagic properties. Desmopressin acetate has selective affinity for the V2 receptor and acts on the distal kidney tubule by increasing the cellular permeability thereby stimulating water reabsorption. This antidiuretic agent is used in the treatment of central diabetes insipidus. An unrelated action of desmopressin acetate is to increases circulating factor VIII and is used in patients with haemophilia and von Willebrand's disease. ( NCI )] (UMLS (NCI) C0086135) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Hormone =1-Deamino-8-D-arginine Vasopressin;
=DESMOPRESSIN ACETATE 150 MCG/ACTUAT;
DESMOPRESSIN ACETATE 0.1 MG/ML;
DESMOPRESSIN ACETATE 4 MCG/ML |
- 503. 1,4,5,8-Tetraamino Anthraquinone
- [A blue to black colored aminoanthraquinone dye. Disperse blue 1 is primarily used in hair color formulations and in coloring fabrics and plastics, but has also been used as a fabric dye. Exposure to disperse blue 1 irritates the eye and skin. Disperse blue 1 is a mutagen and is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0082319) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid ;
| - 553. 1-(3-Methylaminopropyl)dibenzo(b,e)bicyclo(2.2.2)octadiene Hydrochloride
- [The hydrochloride salt form of maprotiline, a tetracyclic antidepressant closely related to the tricyclic antidepressants with adrenergic activity and sedative properties. Maprotiline hydrochloride exerts its effect by blocking the re-uptake of norepinephrine, thereby increasing the synaptic concentration of norepinephrine in the central nervous system and subsequently prolonging the action of norepinephrine on central receptors. ( NCI )] (UMLS (NCI) C0700455) =Organic Chemical; Pharmacologic Substance =MAPROTILINE;
=MAPROTILINE HYDROCHLORIDE 25 MG;
MAPROTILINE HYDROCHLORIDE 50 MG;
MAPROTILINE HYDROCHLORIDE 75 MG |
- 504. 1,4,5,8-Tetroxyantraquinone
- [A reddish, synthetic anthraquinone derivative. Danthron has been widely used as a laxative, but is no longer used to treat constipation and is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes. This substance is a suspected mutagen and is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05) ( NCI )] (UMLS (NCI) C0057135) =Organic Chemical; Pharmacologic Substance ;
=Anthracenedione;
Inactive Ingredient Preparations =DANTHRON 75 MG | - 554. 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone
- [synthetic coumarin anticoagulant. ( CSP )] (UMLS (NCI) C0043031) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance =4-Hydroxycoumarins;
[BL100] ANTICOAGULANTS;
2H-1-Benzopyran-2-one;
=Prothromadin;
|
- 505. 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetramethylene-Phosphonic Acid
- [A bone-seeking chelating agent. Has been used as a radiopharmaceutical in complexes with radioactive metals for bone marrow ablation. ( NCI )] (UMLS (NCI) C0217981) =Organophosphorus Compound; Pharmacologic Substance ;
| - 555. 1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedione
- [A sunscreen blocker. Avobenzone is a topical, broad range UV protector and blocks UVA I, UVA II, and UVB wavelengths, thereby limiting the impact of UV rays on skin. (NCI05) ( NCI )] (UMLS (NCI) C0097513) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance =parsol 1789;
[DE300] SUN PROTECTANTS/SCREENS, TOPICAL =SUNSCREEN-15 PABA-FREE COMBINATION GEL;
SUNSCREEN 30/AVOBENZONE/PABA-FREE LOTION;
SUNSCREEN-15/AVOBENZONE/PABA-FREE LOTION;
AVOBENZONE 3 % |
- 506. 1,4-Benzenediamine, 2,6-Dichloro-N(sup 1)-(4,5-dihydro-1H-imidazol-2-yl), Monohydrochloride
- [The hydrochloride salt form of apraclonidine, a clonidine derivative with selective alpha-2-adrenergic agonistic property. When administered directly to teyes, apraclonidine hydrochloride enhances aqueous humor outflow and decreases aqueous production by vasoconstriction. It is used mostly in ophthalmic preparations for decreasing intraocular pressure. ( NCI )] (UMLS (NCI) C0304657) =Organic Chemical; Pharmacologic Substance ;
=4-aminoclonidine;
=APRACLONIDINE HYDROCHLORIDE 0.5 %;
APRACLONIDINE HYDROCHLORIDE 1 % | - 556. 1-(4-(2-Cyclopropylmethoxy)ethyl)phenoxy)-3-))1-methylethyl)amino)-2-propanol
- [A racemic mixture and selective beta-1 adrenergic receptor antagonist with antihypertensive and anti-glaucoma activities and devoid of intrinsic sympathomimetic activity. Betaxolol selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart, thereby decreasing cardiac contractility and rate. This leads to a reduction in cardiac output and lowers blood pressure. When applied topically in the eye, this agent reduces aqueous humor secretion and lowers the intraocular pressure (IOP). In addition, betaxolol prevents the release of renin, a hormone secreted by the kidneys that causes constriction of blood vessels. ( NCI )] (UMLS (NCI) C0005320) =Organic Chemical; Pharmacologic Substance ;
|
- 507. 1,4-Benzenedicarboximidamide
- [A derivative of the phthalanilide compounds. Terephthalamidine belongs to a family of compounds which appear to reversibly bind to the minor groove of the DNA double helix but not intercalate DNA. This agent also has been suggested to form ionic complexes with many biological components in vitro, including nucleic acids, proteins and lipids. ( NCI )] (UMLS (NCI) C0076116) =Organic Chemical; Pharmacologic Substance
| - 557. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine
- [1-(4-amino-6,7-dimethoxy- 2-quinazolinyl) -4-(2-furoyl) piperazine. ( CSP )] (UMLS (NCI) C0032912) =Organic Chemical; Pharmacologic Substance ;
=antihypertensive agent;
PIPERAZINE;
quinazoline;
[CV150] ALPHA-BLOCKERS/RELATED =Terazosin;
DOXAZOSIN;
PRAZOSIN HYDROCHLORIDE;
PRAZOSIN 5 MG;
PRAZOSIN 1 MG |
- 508. 1,4-bis[[2-[(2-Hydroxyethyl)amino]ethyl]amino]9,10-anthracenedione
- [A topoisomerase II inhibitor of the anthrapyrazole family that causes covalent cross-links in DNA of tumor cells. ( NCI )] (UMLS (NCI) C0102923) =Organic Chemical; Pharmacologic Substance
| - 558. 1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-1-H-indole-3-acetic acid
- [non-steroidal anti-inflammatory agent that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids; also inhibits the motility of polymorphonuclear leukocytes. ( CSP )] (UMLS (NCI) C0021246) =Organic Chemical; Pharmacologic Substance =Indole;
cyclooxygenase inhibitor;
methoxyindole;
[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC;
immunomodulator;
=KETOROLAC TROMETHAMINE;
Indomethacin Sodium;
INDOMETHACIN POWDER (GM);
Indomethacin Sodium;
INDOMETHACIN 25 MG;
INDOMETHACIN 25 MG/5ML;
INDOMETHACIN 50 MG;
INDOMETHACIN 75 MG;
|
- 509. 1,4-Diamino-2,3-dicyano-1,4- bis(2-aminophynyltio)butadiene
- (UMLS (NCI) C0755559) Bis[amino[(2-aminophenyl)thio]methylene]butanedinitrile =Organic Chemical; Pharmacologic Substance ;
| - 559. 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone
- [An azetidinone derivative and a cholesterol absorption inhibitor with lipid-lowering activity. Ezetimibe appears to interact physically with cholesterol transporters at the brush border of the small intestine and inhibits the intestinal absorption of cholesterol and related phytosterols. As a result, ezetimibe causes a decrease in the level of blood cholesterol or an increase in the clearance of cholesterol from the bloodstream. Overall, the following effects observed are a reduction of hepatic cholesterol stores and a reduction of total cholesterol, LDL cholesterol, and other triglycerides in the blood. ( NCI )] (UMLS (NCI) C1142985) EZETIMIBE;
EZETIMIBE PREPARATION =Organic Chemical; Pharmacologic Substance ;
=[CV350] ANTILIPEMIC AGENTS;
Unclassified Ingredients =EZETIMIBE 10 MG;
|
- 510. 1,4-Dichlor-B
- [A synthetic, white crystalline solid that is practically insoluble in water and soluble in ether, chloroform, carbon disulfide, benzene, alcohol and acetone. It is used primarily as a space deodorant in products such as room deodorizers, urinal and toilet bowl blocks, and as an insecticide fumigant for moth control. When 1,4-dichlorobenzene is heated to decomposition, toxic gases and vapors (such as hydrochloric acid and carbon monoxide) are released. The primary route of potential human exposure to this compound is inhalation. Acute inhalation exposure to 1,4-dichlorobenzene can result in coughing and breathing difficulties. Breathing high levels of this chemical can cause headaches, dizziness and liver damage. Contact with 1,4-dichlorobenzene can irritate the eyes, leading to burning and tearing. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0048243) =Organic Chemical; Hazardous or Poisonous Substance
| - 560. 1-(5-Chloro-3-(2-chlorophenyl)-1-(3,4-dimethoxybenzenesulfonyl)-3-hydroxy-2,3-dihydro-1H-indole-2-carbonyl)pyrrolidine-2-carboxamide
- (UMLS (NCI) C0218068) =Organic Chemical; Pharmacologic Substance ;
|
- 511. 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid
- [A synthetic, broad-spectrum fluoroquinolone with antibacterial activity. Norfloxacin inhibits activity of DNA gyrase, thereby blocking bacterial DNA replication. Norfloxacin concentrates in the renal tubules and bladder and is bactericidal against a wide range of aerobic gram-positive and gram-negative organisms. ( NCI )] (UMLS (NCI) C0028365) =Organic Chemical; Pharmacologic Substance ;
=Quinolones;
[AM900] ANTI-INFECTIVES, OTHER =NORFLOXACIN 400 MG;
NORFLOXACIN 0.3 % | - 561. 1-(alpha-methoxymethyl ethanol)-2-Nitroimidazole
- [1-(alpha-methoxymethyl ethanol)-2-nitroimidazole; trichimonicide and experimental mutagen and radiosensitizer, probably due to its ability to form DNA-attacking free radical under hypoxic conditions. ( CSP )] (UMLS (NCI) C0026218) =Organic Chemical; Pharmacologic Substance =Antiprotozoal Agent;
imidazole;
Radiation Sensitizers;
|
- 512. 1,4-Dimethyl-2,3-benzphenanthrene
- [polycyclic aromatic hydrocarbon that is a potent carcinogen. ( CSP )] (UMLS (NCI) C0000677) =Organic Chemical; Hazardous or Poisonous Substance
| - 562. 1-(aminomethyl)cyclohexaneacetic Acid
- [A substance that is being studied as a treatment for relieving hot flashes in women with breast cancer. It belongs to the family of drugs called anticonvulsants. ( NCI )] (UMLS (NCI) C0060926) =Organic Chemical; Pharmacologic Substance ;
=Acetic Acids;
[CN400] ANTICONVULSANTS =GABAPENTIN 100 MG;
GABAPENTIN 300 MG;
GABAPENTIN 400 MG;
GABAPENTIN 600 MG;
GABAPENTIN 800 MG;
GABAPENTIN 250 MG/5ML |
- 513. 1,4-Epoxy-1,3-butadiene
- [compounds with a 5-membered ring of four carbons and an oxygen; aromatic heterocycles; the reduced form is tetrahydrofuran. ( CSP )] (UMLS (NCI) C0060850) =Organic Chemical =oxygenous heterocyclic compound;
=benzofuran;
N-[2-[[[5-[(Dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine | - 563. 1-(Isopropylamino)-3-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)propan-2-ol Hydrochloride
- [The hydrochloride salt form of betaxolol, a beta-1-selective adrenergic receptor antagonist without intrinsic sympathomimetic activity. Betaxolol hydrochloride acts on the heart and circulatory system and decreases cardiac contractility and rate, thereby reducing cardiac output. When applied topically in the eye, it lowers intraocular pressure by reducing aqueous humor secretion. ( NCI )] (UMLS (NCI) C0543470) =Organic Chemical; Pharmacologic Substance =1-(4-(2-Cyclopropylmethoxy)ethyl)phenoxy)-3-))1-methylethyl)amino)-2-propanol;
=BETAXOLOL HYDROCHLORIDE 0.25 %;
BETAXOLOL HYDROCHLORIDE 0.5 %;
BETAXOLOL HYDROCHLORIDE 10 MG;
BETAXOLOL HYDROCHLORIDE 20 MG;
|
- 514. 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, Phosphate (1:2)
- [The phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids. ( NCI )] (UMLS (NCI) C0055447) =Organic Chemical; Pharmacologic Substance =chloroquine;
=Chloroquine Hydrochloride;
CHLOROQUINE PHOSPHATE 250 MG;
CHLOROQUINE PHOSPHATE 500 MG | - 564. 1-(p-Acetylbenzenesulfonyl)-3-Cyclohexylurea
- [A sulfonylurea with oral hypoglycemic properties that is used in the treatment of Type II diabetes mellitus. Acetohexamide lowers blood sugar by stimulating insulin release from the pancreas and increases the sensitivity of beta cells to glucose stimulus. This drug also increases the sensitivity of insulin receptors in muscle, liver, and adipose tissue thereby promoting glucose transport across cell membranes. This results in better controlled blood glucose levels. (NCI05) ( NCI )] (UMLS (NCI) C0000992) =Organic Chemical; Pharmacologic Substance ;
|
- 515. 1,4-Phenylenebis(methylene)selenocyanate
- (UMLS (NCI) C0167369) =Organic Chemical; Pharmacologic Substance ;
| - 565. 1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)diethylenediamine Hydrochloride
- [The hydrochloride salt form of hydroxyzine, a piperazine histamine H1-receptor antagonist with anti-allergic, antispasmodic, sedative, anti-emetic and anti-anxiety properties. Hydroxyzine hydrochloride blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilatation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. In addition, hydroxyzine hydrochloride crosses the blood-brain barrier and acts on the histamine H1-receptors in the central nervous system. (NCI05) ( NCI )] (UMLS (NCI) C0600110) =Organic Chemical; Pharmacologic Substance =HYDROXYZINE;
=HYDROXYZINE HYDROCHLORIDE 100 MG;
HYDROXYZINE HYDROCHLORIDE 25 MG;
HYDROXYZINE HYDROCHLORIDE 50 MG;
HYDROXYZINE HYDROCHLORIDE 50 MG/ML;
HYDROXYZINE HYDROCHLORIDE 10 MG;
HYDROXYZINE HYDROCHLORIDE 25 MG/ML;
HYDROXYZINE HYDROCHLORIDE 10 MG/5ML |
- 516. 1,4-Pregnadiene-2,20-dione-16,17-cyclopentylidenedioxy-9-fluoro-11,21-dihydroxy-21-acetate
- [A synthetic glucocorticoid receptor agonist that mimics the metabolic, anti-inflammatory, and immunosuppressive activity of the natural glucocorticoids. Amcinonide interacts with specific corticosteroid receptors and was internalized, which leads to binding of DNA and modification of gene expression. This results in synthesis of anti-inflammatory mediators while inhibiting synthesis of inflammatory mediators. Consequently, an overall reduction in chronic inflammation and autoimmune reactions are achieved. ( NCI )] (UMLS (NCI) C0051556) =Steroid; Pharmacologic Substance =(11beta,16alpha)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;
[DE200] ANTI-INFLAMMATORY, TOPICAL =AMCINONIDE 0.1 % | - 566. 1-(p-Chlorophenyl)-5-isopropylbiguanide Hydrochloride
- [The hydrochloride salt form of proguanil, a synthetic biguanide derivative of pyrimidine and an folate antagonist with antimalarial property. Upon hydrolysis, proguanil is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite. ( NCI )] (UMLS (NCI) C0546856) =Organic Chemical; Pharmacologic Substance
|
- 517. 1,4:3,6-Dianhydro-D-glucitol 5-nitrate
- [The mononitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide mononitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide mononitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05) ( NCI )] (UMLS (NCI) C0064079) =Organic Chemical; Pharmacologic Substance ;
=ISOSORBIDE;
ISOSORBIDE DINITRATE =ISOSORBIDE MONONITRATE 120 MG;
ISOSORBIDE MONONITRATE 10 MG;
ISOSORBIDE MONONITRATE 20 MG;
ISOSORBIDE MONONITRATE 60 MG;
ISOSORBIDE MONONITRATE 30 MG | - 567. 1-(p-Hydroxyphenyl)-2-(1'-methyl-2'-phenoxy)ethylaminopropanol-1 Hydrochloride
- [The hydrochloride salt of isoxsuprine, a benzyl alcohol derivative with vasodilator activity. The mechanism of action of isoxsuprine hydrochloride is controversial because this drug has beta-adrenergic agonist activities that are not reversed by beta-adrenergic blockers. Although stimulation of the beta adrenergic receptor increases blood flow to produce vasodilatation, this drug may also have direct effects on the contractility of smooth muscle. Isoxsuprine hydrochloride also causes relaxation of uterine smooth muscle and may also produce positive inotropic and chronotropic effects on the myocardium. ( NCI )] (UMLS (NCI) C0282213) =Organic Chemical; Pharmacologic Substance =ISOXSUPRINE;
=ISOXSUPRINE HYDROCHLORIDE 10 MG;
ISOXSUPRINE HYDROCHLORIDE 20 MG |
- 518. 1,5-(butylimino)-1,5-dideoxy-D-glucitol
- [A synthetic, N-alkylated imino analogue of D-glucose. Miglustat competitively and reversibly binds to and inhibits the activity of UDP-glucose ceramide glucosyltransferase, which catalyzes the initial step in the synthesis of glycosphingolipids (GSL). This leads to a decrease in the production of glycosphingolipid, which has important roles in various cellular processes. Miglustat can be used in substrate reduction therapy in diseases in which the enzyme glucocerebrosidase, that is responsible for the breakdown of GSL, is deficient. ( NCI )] (UMLS (NCI) C1321596) 3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-,(2R-(2alpha,3beta,4alpha,5beta))-;
MIGLUSTAT;
MIGLUSTAT PREPARATION;
N-Butyl Deoxynojirimycin;
N-Butylmoranoline =Organic Chemical; Pharmacologic Substance =[HS900] HORMONES/SYNTHETICS/MODIFIERS, OTHER;
Unclassified Ingredients =MIGLUSTAT 100 MG | - 568. 1-.beta.-D-Ribofuranosyl-1H-1,2, 4-triazole-3-carboxamide
- [1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamid e; antiretroviral agent with potential efficacy against AIDS. ( CSP )] (UMLS (NCI) C0035525) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
=[AM800] ANTIVIRALS;
ribonucleoside;
Reverse Transcriptase Inhibitor;
nucleoside analog =RIBAVIRIN 200 MG;
RIBAVIRIN 42 X 200 MG;
RIBAVIRIN 70 X 200 MG;
RIBAVIRIN 84 X 200 MG;
RIBAVIRIN 6;
|
- 519. 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(di-methylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-(2S-cis)-,(S)-hydoxybutanedioate(1:1)
- [A benzothiazepine derivative and a calcium channel blocker with vasodilator, antihypertensive and cardiovascular properties. Diltiazem maleate inhibits the influx of calcium ions of coronary and peripheral vascular smooth muscle. This leads to a dilation of peripheral and coronary blood vessels, and results in a reduction of myocardial oxygen requirement and in an increase in myocardial oxygen delivery. In addition, diltiazem maleate has a potent negative chronotropic effect with only a mild negative inotropic effect. This drug is used as an antiarrhythmic and an antianginal agent. ( NCI )] (UMLS (NCI) C0282138) =Organic Chemical; Pharmacologic Substance ;
| - 569. 1-0-Octadecyl-2-O-methyl-Sn-3-glycero-phosphocholine Liposome
- [A liposomal formulation of the ether lipid 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine with potential antineoplastic activity. TLC ELL-12 induces tumor cell apoptosis via mitochondria- and caspase-mediated mechanisms. Liposomal encapsulation reduces the free agent's hemolytic toxicity. (NCI04) ( NCI )] (UMLS (NCI) C1313443) ELL-12;
TLC ELL-12 =Organic Chemical; Pharmacologic Substance ;
|
- 520. 1,5-Dihydro-4H-pyrazolo[3,4-d]pryimidin-4-one
- [drug used to treat gout and other conditions in which there is an excessive buildup of uric acid. ( CSP )] (UMLS (NCI) C0002144) =Organic Chemical; Pharmacologic Substance ;
| - 570. 1-5 years old
- [a human child aged 1 through 5 years of age; may include kindergarten age group; also index with appropriate human and clinical research terms. ( CSP )] (UMLS (CSP) C0008100) =Age Group ;
=child (0-11);
|
- 521. 1,5-Dihydro-4H-pyrazolo[3,4-d]pryimidin-4-one Monosodium Salt
- [The sodium form of allopurinol, which is a structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies. (NCI04) ( NCI )] (UMLS (NCI) C0278766) =Organic Chemical; Pharmacologic Substance
| - 571. 1-ABaP
- [A polycyclic aromatic hydrocarbon belongs to the family of mutagen benzo(a)pyrene. 1-aminobenzo(a)pyrene consists of five fused rings with an amino-group attached to the first carbon atom of the aromatic hydrocarbon ring with potential carcinogenicity. ( NCI )] (UMLS (NCI) C0768966) 1-Aminobenzo[a]pyrene;
=Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance |
- 522. 1,6-Dinitropyrene
- [A synthetic, yellow crystalline solid that is insoluble in water and moderately soluble in toluene. It is not used for any commercial applications and is used only for research purposes. When heated to decomposition, 1,6-dinitropyrene emits toxic fumes of nitrogen oxides. 1,6-dinitropyrene is found in particulate emissions from combustion products, of which diesel exhaust is the principle source. The primary route of potential human exposure to this chemical is inhalation. 1,6-dinitropyrene has been detected at low concentrations in ambient air. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0044050) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 572. 1-Acetamido-4-ethoxybenzene
- [A synthetic, white crystalline solid that is slightly soluble in water and benzene, soluble in acetone and very soluble in pyrimidine. It is used in research as the preferred marker for detecting CYP1A2-based inhibition potential in vitro. Human ingestion of phenacetin can result in a bluish discoloration of the skin due to a lack of oxygen in the blood (cyanosis), dizziness and respiratory depression. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0031364) =Organic Chemical; Pharmacologic Substance =Acetanilides;
[CN850] ANTIPYRETICS;
[CN103] NON-OPIOID ANALGESICS;
TO BE DELETED INGREDIENT PREPARATIONS;
Unclassified Ingredient Preparations;
|
- 523. 1,7-Dihydro-6H-purine-6-thione
- [An anticancer drug that belongs to the family of drugs called antimetabolites. ( NCI )] (UMLS (NCI) C0000618) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
| - 573. 1-Acetyl-2-picolinoylhydrazine
- [A hydrazine compound that has been investigated for antineoplastic activity. (NCI04) ( NCI )] (UMLS (NCI) C0052754) =Organic Chemical; Pharmacologic Substance
|
- 524. 1,7-Heptanediyl Ester Sulfamic Acid
- [A bisulfamic ester which is similar in structure to busulfan and belongs to the family of drugs known as alkylsulfonate alkylating agents. Hepsulfam forms covalent linkages with nucleophilic centers in DNA, resulting in depurination, base miscoding, strand scission, DNA-DNA and DNA-protein cross-linking, and cytotoxicity. (NCI04) ( NCI )] (UMLS (NCI) C0062540) =Organic Chemical; Pharmacologic Substance ;
| - 574. 1-Allyl-3,4-methylenedioxybenzene
- [A naturally-occurring, colorless to slightly yellow liquid that is soluble in ethanol, ether, and chloroform. Safrole is no longer used in the United States. Minimal exposure to safrole may occur through the use of edible spices, including nutmeg and mace, which contain low levels of this compound. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0036049) =Organic Chemical; Hazardous or Poisonous Substance
|
- 525. 1,8-Dihydroxy-9(10H)-anthracenone
- [A natural anthraquinone derivative, anti-psoriatic and anti-inflammatory Anthralin (dithranol) controls skin growth by reducing DNA synthesis and mitotic activity in the hyperplastic epidermis, restoring a normal rate of cell proliferation and keratinization. Used topically in the treatment of psoriasis, dermatoses, and alopecia areata, it is also used in biomedical research due to its effect on EGFR autophosphorylation. (NCI04) ( NCI )] (UMLS (NCI) C0003166) =Organic Chemical; Pharmacologic Substance
| - 575. 1-Amino-2,4-dibromo-9,10-anthracenedione
- [A synthetic, light sensitive, red powder that is insoluble in water and soluble in many organic solvents. It is used as both an intermediate for the production of anthraquinone dyes and as a starting material for the manufacture of vat dyes. The primary route of potential human exposure to 1-amino-2,4-dibromoanthraquinone is dermal contact. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0626387) =Organic Chemical
|
- 526. 1,8-Dinitropyrene
- [A synthetic, yellow crystalline solid that is insoluble in water and moderately soluble in toluene. It is not used for any commercial applications and is used only for research purposes. When heated to decomposition, 1,8-dinitropyrene emits toxic fumes of nitrogen oxides. 1,8-dinitropyrene is found in particulate emissions from combustion products, of which diesel exhaust is the principle source. The primary route of potential human exposure to this chemical is inhalation. Detectable levels of 1,8-dinitropyrene have been found in respirable particulates from ambient atmospheric samples. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0044067) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 576. 1-Amino-2-methyl-9,10-anthracenedione
- [A synthetic, red powder that is insoluble in water and soluble in acetone, ethanol, ether, benzene, chloroform and acetic acid. It is used almost exclusively as a dye and dye intermediate for the production of a variety of anthraquinone dyes. The primary routes of potential human exposure to 1-amino-2-methylanthraquinone are inhalation and dermal contact. However, human exposure is limited because this compound is no longer produced in the United States. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0044271) =Organic Chemical
|
- 527. 1,8-Naphthyridine-3-carboxylic Acid, 1-ethyl-1,4-dihydro-7-methyl-4-oxo-
- [A synthetic quinolone and antibacterial agent with urinary tract antiseptic activity. Nalidixic acid concentrates in the renal tubules and bladder and exerts its local antibacterial actions by interference of DNA gyrase activity, thereby inhibiting DNA synthesis during bacterial replication in a dose-dependent manner. Nalidixic acid is active against most gram-negative organisms that cause urinary tract infections. ( NCI )] (UMLS (NCI) C0027353) =Organic Chemical; Pharmacologic Substance =Naphthyridines;
[AM900] ANTI-INFECTIVES, OTHER =Nalidixate 250 MG;
Nalidixate 500 MG;
NALIDIXIC ACID 1 GM;
NALIDIXIC ACID 250 MG/5ML;
| - 577. 1-amino-3,5-dimethyladamantane Hydrochloride
- [The hydrochloride salt form of memantine, a moderate affinity, noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Memantine hydrochloride exerts its effect by binding to the cation channels on the NMDA receptor located in the central nervous system, thereby blocking the NMDA receptor and preventing the binding of the excitatory amino acid glutamate. This results in a reduction of abnormal excitement in the brain, which is often seen in Alzheimer's disease. Memantine hydrochloride also acts as an antagonist at the 5HT 3 receptor and the nicotinic receptor. ( NCI )] (UMLS (NCI) C0771988) Ebixia;
MEMANTINE HYDROCHLORIDE =Organic Chemical; Pharmacologic Substance ;
|
- 528. 1,9-Dihydro-2-amino-9-(4-hydroxy-3-(hydroxymethyl)butyl)-6H-purin-6-one Monosodium Salt
- [The sodium salt form of penciclovir, a synthetic acyclic guanine derivative with antiviral activity, mainly used to treat infections from herpes simplex virus (HSV) types 1 and 2. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited. ( NCI )] (UMLS (NCI) C0892839) 9-(4-Hydroxy-3-(hydroxymethyl)butyl)guanine, Monosodium Salt;
PENCICLOVIR SODIUM;
=Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance | - 578. 1-Amino-6,17-dihydroxy-7,10,18,21-tetraoxo-27-(n-acetylhydroxylamino)-6,11,17,22-tetraazaheptaeicosane
- [natural product isolated from Streptomyces pilosus; it forms iron complexes and is used as a chelating agent, particularly in the mesylate form. ( CSP )] (UMLS (NCI) C0011145) =Organic Chemical; Biologically Active Substance; Indicator, Reagent, or Diagnostic Aid =chelating agent;
Hydroxamic Acids;
hydroxamate;
[AD300] HEAVY METAL ANTAGONISTS =DEFEROXAMINE MESYLATE;
|
- 529. 1,9-Nonanedioic Acid
- [A naturally occurring dicarboxylic acid produced by Malassezia furfur andfound in whole grain cereals, rye, barley and animal products. Azelaic acid possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity. Azelaic acid is bactericidal against Proprionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular proteins. Azelaic acid exerts its keratolytic and comedolytic effects by reducing the thickness of the stratum corneum and decreasing the number of keratohyalin granules by reducing the amount and distribution of filaggrin in epidermal layers. Azelaic acid also possesses a direct anti-inflammatory effect due to its scavenger activity of free oxygen radical. This drug is used topically to reduce inflammation associated with acne and rosacea. ( NCI )] (UMLS (NCI) C0052761) =Organic Chemical; Pharmacologic Substance =Dicarboxylic Acids;
[DE752] ANTIACNE AGENTS, TOPICAL =AZELAIC ACID 15 %;
AZELAIC ACID 20 %;
| - 579. 1-Aminocyclopentane
- [A synthetic amino acid derivative of cyclopentanecarboxylic acid, Cycloleucine displays immunosuppressive, antineoplastic, and cytostatic properties. Believed to act in vivo as a valine antagonist and an NMDA receptor antagonist acting at the glycine site, Cycloleucine is a competitive inhibitor of many enzymes, such as methionine adenosyltransferase (S-adenosylmethionine biosynthesis). Toxicity is correlated with a block of nucleic acid methylation; cell cycle progression; and DNA, RNA and protein biosynthesis. (NCI04) ( NCI )] (UMLS (NCI) C0010575) =Amino Acid, Peptide, or Protein; Pharmacologic Substance
|
- 530. 1,9-Nonanediol
- [An aliphatic alcohol (with nine carbon atoms and two hydroxyl groups at positions 1 and 9) used in chemical synthesis and biomedical research. 1,9-Nonanediol suppresses glycine currents in neurons; glycine is a major inhibitory neurotransmitter in the mature mammalian central nervous system. (NCI04) ( NCI )] (UMLS (NCI) C0657542) =Organic Chemical
| - 580. 1-beta-D-Ribofuranosyl-2(1H)-pyrimidinone
- [A synthetic cytidine analogue and a cytidine deaminase inhibitor with anticancer activity. Following metabolic activation by phosphorylation and incorporation into DNA, zebularine inhibits DNA methyltransferase through covalent complex formation between the enzyme and zebularine-substituted DNA, hence resulting in non-specific, genome-wide induction of demethylation including the removal of aberrant methylation of promoter regions of genes critical for normal cellular functions. ( NCI )] (UMLS (NCI) C0084253) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
|
- 531. 1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol
- [noncardioselective beta adrenergic antagonist; used in treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hyperthyroidism, migraine; pheochromocytoma, etc. ( CSP )] (UMLS (NCI) C0033497) =Organic Chemical; Pharmacologic Substance ;
=[CV300] ANTIARRHYTHMICS;
Propanolamines;
beta antiadrenergic agent;
naphthylamine;
coronary vasodilator;
[CV100] BETA-BLOCKERS/RELATED =2-Propanol-1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy) Hydrochloride;
PROPRANOLOL 10 MG;
PROPRANOLOL 40 MG;
| - 581. 1-bis(2-chloroethyl)-amino-1-oxo-2-aza-5-oxaphosphoridin monohydrate
- (UMLS (NCI) C0887682) 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate;
2-[bis(b-chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane-2-oxide monohydrate;
2-[di(chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane 2-oxide monohydrate;
2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate;
bis(2-chloroethyl)phosphamide cyclic propanolamide ester monohydrate;
Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate;
CP monohydrate;
Cyclophosphamid monohydrate;
N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)phosphorodiamidic acid intramolecular ester monohydrate;
N,N-bis(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate;
N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate;
N,N-bis(b-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate;
N,N-bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate;
N,N-bis(beta-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate =Organophosphorus Compound; Pharmacologic Substance ;
|
- 532. 1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea
- [A synthetic ergoline derivative and a long-acting dopamine receptor agonist with high affinity for the dopamine D2 receptor. Cabergoline exerts an inhibitory effect on prolactin secretion by acting on dopamine receptors present in pituitary lactotrophes. This drug also binds to dopamine D2 receptors in the corpus striatum, thereby mimicking the actions of dopamine on motor control. Cabergoline also possesses antioxidant and neuroprotective properties due to its free radical scavenging activity. Cabergoline is used in the treatment of Parkinson's disease and in the treatment of hyperprolactinemia. ( NCI )] (UMLS (NCI) C0107994) =Organic Chemical; Pharmacologic Substance =ergoline;
[AU900] AUTONOMIC AGENTS, OTHER =CABERGOLINE 0.5 MG | - 582. 1-Butanone, 1-(4-fluorophenyl)-4-[4-[(4-fluorophenyl)hydroxymethyl]-1-piperidi nyl]-
- [A butyrophenone that has been investigated for antineoplastic activity. (NCI04) ( NCI )] (UMLS (NCI) C0208317) =Organic Chemical; Pharmacologic Substance ;
|
- 533. 1-(11-Dodecylamino-10-Hydroxyundecyl)-3,7-Dimethylxanthine
- (UMLS (NCI) C0539090) =Organic Chemical; Pharmacologic Substance ;
| - 583. 1-Chloro-2,3-epoxypropane
- [A volatile and flammable, clear, colorless, liquid, chlorinated cyclic ether with an irritating, chloroform-like odor that emits toxic fumes of hydrochloric acid and other chlorinated compounds when heated to decomposition. Epichlorohydrin is used in the manufacture of epoxy resins, synthetic glycerin and elastomers. Exposure to epichlorohydrin irritates the eyes, skin and respiratory tract, and can cause chemical pneumonitis, pulmonary edema, and renal lesions. This substance also affects the blood. Epichlorohydrin is reasonably anticipated to be a human carcinogen and may be associated with an increased risk of developing respiratory cancer. (NCI05) ( NCI )] (UMLS (NCI) C0014486) =Organic Chemical; Hazardous or Poisonous Substance ;
|
- 534. 1-(1H-Indol-4-yloxy)-3-((1-methylethyl)amino)-2-propanol
- [An aryloxypropanolamine derivative with antihypertensive property. Pindolol competitively binds to beta-adrenergic receptors, resulting in a decrease in beta-adrenergic activities, i.e., vasodilation, and negative chronotropic and inotropic effects. In addition, this agent blocks serotonin (5-HT) 1A receptors, thereby increasing the available serotonin in the brain. Increased serotonin levels augment the antidepressant action of selective serotonin reuptake inhibitors and monoamine oxidase inhibitors. ( NCI )] (UMLS (NCI) C0031937) =Organic Chemical; Pharmacologic Substance =Propanolamines;
[CV100] BETA-BLOCKERS/RELATED =PINDOLOL 10 MG;
PINDOLOL 5 MG;
| - 584. 1-Chloroisobutylene
- [A clear, colorless, highly volatile and flammable liquid chlorinated hydrocarbon that emits highly toxic fumes of hydrochloric acid and other chlorinated compounds when heated to decomposition. Dimethylvinyl chloride is exclusively used for research purposes in organic synthesis and in the production of isobutylene compounds. This substance is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0044333) =Organic Chemical; Pharmacologic Substance ;
|
- 535. 1-(2,3-Dideoxy-beta-glycero-pent-2-enofuranosyl)thymine
- [nucleoside analog; used as an antiviral agent. ( CSP )] (UMLS (NCI) C0164662) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
=[AM800] ANTIVIRALS;
Dideoxynucleosides;
dT;
1-(2,3-Dideoxy-beta-glycero-pent-2-enofuranosyl)thymine;
2'3' dideoxynucleoside;
=1-(2,3-Dideoxy-beta-glycero-pent-2-enofuranosyl)thymine;
STAVUDINE (d4T) 15 MG;
STAVUDINE (d4T) 20 MG;
STAVUDINE (d4T) 30 MG;
STAVUDINE (d4T) 5 MG/5ML;
STAVUDINE (d4T) 40 MG;
1-(2,3-Dideoxy-beta-glycero-pent-2-enofuranosyl)thymine | - 585. 1-cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol Hydrochloride
- [The hydrochloride salt form of procyclidine, with anticholinergic properties. Procyclidine hydrochloride competitively binds to striatal cholinergic receptors, thereby diminishing acetylcholine activity and ultimately reducing the frequency and severity of akinesia, rigidity, and tremor associated with uncontrollable body movements. In addition, this agent may block the re-uptake of dopamine by nerve terminals, thereby increasing dopamine activity. ( NCI )] (UMLS (NCI) C0546874) =Organic Chemical; Pharmacologic Substance =Procyclidine;
=PROCYCLIDINE HYDROCHLORIDE 5 MG;
|
- 536. 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane
- [psychedelic phenylisopropylamine derivative, commonly called DOM, whose mood altering effects and mechanism of action may be similar to those of LSD. ( CSP )] (UMLS (CSP) C0013007) =Organic Chemical; Pharmacologic Substance ;
=Amfetamine;
| - 586. 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid
- [An anti-infection drug that is also being studied in bladder cancer chemotherapy. ( NCI )] (UMLS (NCI) C0008809) =Organic Chemical; Pharmacologic Substance =Quinolones;
antibacterial agent;
[AM900] ANTI-INFECTIVES, OTHER;
[OP201] ANTIBACTERIALS, TOPICAL OPHTHALMIC =1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid, Monohydrochloride, Monohydrate;
CIPROFLOXACIN 10 MG/ML;
CIPROFLOXACIN 2 MG/ML;
24 HR Ciprofloxacin 500 MG Extended Release Tablet;
24 HR Ciprofloxacin 1000 MG Extended Release Tablet |
- 537. 1-(2-(beta-naphthyloxy)ethyl)-3-methyl-2-pyrazolin-5-one
- [A pyrazolinone derivative with potential antimetastatic activities. Nafazatrom, originally developed as an antithrombotic agent, inhibits the key prostaglandin catabolic enzyme, 15-hydroxyprostaglandin dehydrogenase, thereby prolonging the biological half-life of prostacyclin (prostaglandin I2; PGI2) and preventing intravascular coagulation. This agent also serves as a reducing cofactor with the hydroperoxidase moiety of cyclooxygenase and accelerates the conversion of arachidonic acid into precursors of PGI2. Elevated level of PGI2 prevents aggregation of platelets and subsequently, decreases the formation of tumor cell-platelet aggregates as well as their sequestration in blood vessels, which is an important initiating step in the development of metastasis. ( NCI )] (UMLS (NCI) C0053025) =Organic Chemical; Pharmacologic Substance
| - 587. 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid, Monohydrochloride, Monohydrate
- [The hydrochloride salt form of ciprofloxacin, a fluoroquinolone related to nalidixic acid with antibacterial activity. Ciprofloxacin hydrochloride exerts its bactericidal effect by interfering with the bacterial DNA gyrase, thereby inhibiting the DNA synthesis and preventing bacterial cell growth. ( NCI )] (UMLS (NCI) C0282104) =Organic Chemical; Antibiotic ;
=1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid;
=CIPROFLOXACIN HYDROCHLORIDE 250 MG/5ML;
CIPROFLOXACIN HYDROCHLORIDE 500 MG/5ML;
CIPROFLOXACIN HYDROCHLORIDE 02 %;
CIPROFLOXACIN HYDROCHLORIDE 250 MG;
CIPROFLOXACIN HYDROCHLORIDE 500 MG;
CIPROFLOXACIN HYDROCHLORIDE 750 MG;
CIPROFLOXACIN HYDROCHLORIDE 100 MG;
CIPROFLOXACIN HYDROCHLORIDE 0.3 %;
|
- 538. 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol
- [for the treatment of depression; a norepinephrine reuptake inhibitor ( CSP )] (UMLS (CSP) C0078569) =Organic Chemical; Pharmacologic Substance ;
=[CN600] ANTIDEPRESSANTS;
cyclohexane;
Cyclohexanols;
serotonin inhibitor;
[CN609] ANTIDEPRESSANTS, OTHER;
=Venlafaxine Hydrochloride | - 588. 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid
- [A synthetic 8-methoxyfluoroquinolone with antibacterial activity against a wide range of gram-negative and gram-positive microorganisms. Gatifloxacin exerts its effect through inhibition of DNA gyrase, an enzyme involved in DNA replication, transcription and repair, and inhibition of topoisomerase IV, an enzyme involved in partitioning of chromosomal DNA during bacterial cell division. ( NCI )] (UMLS (NCI) C0753645) Gatifloxacin;
GATIFLOXACIN PREPARATION =Organic Chemical; Antibiotic ;
=[AM900] ANTI-INFECTIVES, OTHER;
Unclassified Ingredients =GATIFLOXACIN 10 MG/ML;
GATIFLOXACIN 200 MG;
GATIFLOXACIN 400 MG;
GATIFLOXACIN 2 MG/ML;
GATIFLOXACIN 0.3 %;
|
- 539. 1-(2-chloroethyl)-1-nitroso-3-(D-glucos-2-yl)urea
- [A glucose-linked chloroethylnitrosourea with potential antineoplastic activity. Chlorozotocin alkylates DNA and proteins, induces the formation of interstrand DNA and DNA-protein crosslinks, and causes DNA strand breakage, thereby damaging DNA and resulting in cell death. This agent has been shown to exhibit antitumor and immunomodulatory effects in cell lines and animal models. Chlorozotocin is a mutagen and is less myelotoxic than other nitrosoureas. (NCI04) ( NCI )] (UMLS (NCI) C0055465) =Organic Chemical; Antibiotic
| - 589. 1-De(5-oxo-L-proline)-2-de-L-glutamine-5-L-methioninecaerulein
- [A synthetic C-terminal octapeptide identical to the sequences of the endogenous cholecystokinin hormone. Mimic action of cholecystokinin, sincalide induces gallbladder smooth muscle contraction directly, thereby reducing gallbladder size, inducing bile evacuation, and secretion of pancreatic enzymes. In addition, this agent decreases esophageal sphincter tone and delays gastric emptying via cholinergic signaling. ( NCI )] (UMLS (NCI) C0037167) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Hormone =CCK;
[DX101] NON-IONIC CONTRAST MEDIA =SINCALIDE 5 MCG;
|
- 540. 1-(2-Chloroethyl)-3-(2,6-Dioxo-3-Piperidyl)-1-Nitrourea
- [A chloroethylnitrosourea compound and an alkylating agent with antineoplastic property. PCNU inhibits DNA synthesis by alkylating DNA and causing DNA cross links, thereby inducing apoptosis. In addition, this agent may be associated with pulmonary, hepatic, and hematologic toxicities. Unlike other nitrosoureas, PCNU has strong alkylating while weak carbamoylating activity. ( NCI )] (UMLS (NCI) C0070165) =Organic Chemical; Pharmacologic Substance
| - 590. 1-Deamino-8-D-arginine Vasopressin
- [A synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. Desmopressin binds to V2 receptors in renal collecting ducts which leads to exocytosis of von Willebrand factor (VWF) and tissue plasminogen activator (t-PA) from Weibel-Palade bodies, thereby increasing water resorption. This agent also increases nitric oxide (NO) production via activation of endothelial NO synthase, thereby induces afferent arteriolar vasodilation. Furthermore, desmopressin stimulates the release of factor VIII from endothelial cells mediated through V1a receptor, thereby promotes blood coagulation. ( NCI )] (UMLS (NCI) C0011701) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Hormone =[HS702] POSTERIOR PITUITARY;
ADH =1-(3-Mercaptopropionic acid)-8-D-arginine Vasopression Monoacetate;
DESMOPRESSIN 0.1 MG;
DESMOPRESSIN 0.2 MG |
- 541. 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
- [An anticancer drug that belongs to the family of drugs called alkylating agents. ( NCI )] (UMLS (NCI) C0036637) =Organic Chemical; Pharmacologic Substance ;
| - 591. 1-Deoxy-1-(methylamino)-D-glucitol 3,5-diacetamido-2,4,6-triiodobenzoate (salt)
- [The meglumine salt form of diatrizoate, an organic, iodinated, radiopaque X-ray contrast medium used in diagnostic radiography. The iodine moiety of diatrizoate meglumine is not penetrable by X-rays, therefore blocks the X-ray film exposure by radiation. This makes it possible to distinguish on X-ray film, body parts that contain diatrizoate meglumine from body parts that do not contain this agent and allows for visualization of different body structures. ( NCI )] (UMLS (NCI) C0012005) =Organic Chemical; Pharmacologic Substance; Indicator, Reagent, or Diagnostic Aid =3,5-Bis(acetylamino)-2,4,6-triiodobenzoic Acid;
MEGLUMINE;
Triiodobenzoic Acids;
=3,5-Diacetamido-2,4,6-triiodobenzoic Acid, Sodium Salt;
DIATRIZOATE MEGLUMINE 520 MG/ML;
DIATRIZOATE MEGLUMINE 52 %;
DIATRIZOATE MEGLUMINE 660 MG;
DIATRIZOATE MEGLUMINE 76 %;
DIATRIZOATE MEGLUMINE 34.3 %;
DIATRIZOATE MEGLUMINE 30 %;
DIATRIZOATE MEGLUMINE 85 %;
DIATRIZOATE MEGLUMINE 52.7 %;
DIATRIZOATE MEGLUMINE 18 %;
DIATRIZOATE MEGLUMINE 60 %;
DIATRIZOATE MEGLUMINE 28.5 %;
DIATRIZOATE MEGLUMINE 66 %;
DIATRIZOATE MEGLUMINE 50 % |
- 542. 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
- [cytotoxic alkylating agent of the nitrosourea group used as an antineoplastic. ( CSP )] (UMLS (NCI) C0023972) =Organic Chemical; Pharmacologic Substance =[AN000] ANTINEOPLASTICS;
nitrosourea;
Antineoplastic Alkylating Agent;
=LOMUSTINE 10 MG;
LOMUSTINE 100 MG;
LOMUSTINE 40 MG;
LOMUSTINE 300 MG;
| - 592. 1-Deoxy-1-(methylamino)-D-glucitol 3-((((3-(acetylmethylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)benzoyl)amino)acetyl)amino)-5-(((2-hydroxyethyl)amino)carbonyl)-2,4,6-triiodobenzoate
- [The meglumine salt form of ioxaglate, an organic iodine compound and a radiographic contrast medium. Ioxaglate meglumine blocks x-rays as they pass through the body, thereby allowing body structures not containing iodine to be visualized. The degree of opacity produced by ioxaglate meglumine is directly proportional to the total amount of the iodinated contrast agent in the path of the x-rays. The visualization of body structures is dependent upon the distribution and elimination of ioxaglate meglumine. (NCI05) ( NCI )] (UMLS (NCI) C0205807) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid =IOXAGLATE;
=IOXAGLATE MEGLUMINE 393 MG/ML;
|
- 543. 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil
- [antineoplastic antimetabolite; has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. ( CSP )] (UMLS (NCI) C0016343) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
=[AN300] ANTINEOPLASTICS, ANTIMETABOLITES;
[AN000] ANTINEOPLASTICS;
[AM800] ANTIVIRALS;
deoxyuridine;
fluoropyrimidine;
halocarbon compound;
nucleoside analog;
=FLOXURIDINE 100 MG/ML;
| - 593. 1-Deoxy-1-(methylamino)-D-glucitol 3-(acetylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)benzoate
- [The meglumine salt form of iothalamate, an organic iodine compound and a radiographic contrast medium. Iothalamate meglumine blocks x-rays as they pass through the body, thereby allowing body structures not containing iodine to be visualized. The degree of opacity produced by iothalamate meglumine is directly proportional to the total amount of the iodinated contrast agent in the path of the x-rays. The visualization of body structures is dependent upon the distribution and elimination of iothalamate meglumine. (NCI05) ( NCI )] (UMLS (NCI) C0022033) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid =IOTHALAMATE;
MEGLUMINE;
Triiodobenzoic Acids;
=Benzoic Acid, 3-(acetylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)-, Monosodium Salt;
IOTHALAMATE MEGLUMINE 60 %;
IOTHALAMATE MEGLUMINE 43 %;
IOTHALAMATE MEGLUMINE 17.2 %;
IOTHALAMATE MEGLUMINE 30 %;
IOTHALAMATE MEGLUMINE 52 %;
|
- 544. 1-(2-Deoxy-beta-D-ribofuranosyl)-5-iodouracil
- [pyrimidine analog which inhibits viral DNA synthesis. ( CSP )] (UMLS (NCI) C0020811) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
=[AM800] ANTIVIRALS;
deoxyuridine;
halocarbon compound;
[OP203] ANTIVIRALS, TOPICAL OPHTHALMIC;
nucleoside analog;
| - 594. 1-Epoxyethyl-3,4-epoxycyclohexane
- [A synthetic, colorless liquid that is soluble in water. It is used as a reactive diluent for other epoxides and as a monomer in the production of epoxy resins for coatings and adhesives. Occupational exposure of humans to 4-vinyl-1-cyclohexene diepoxide results in skin irritation. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0048737) =Organic Chemical; Hazardous or Poisonous Substance ;
|
- 545. 1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
- [antimetabolite used in the treatment of pancreatic, lung, and other cancers. ( CSP )] (UMLS (NCI) C0045093) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
=antimetabolite;
[AN000] ANTINEOPLASTICS;
deoxycytidine;
=1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose, hydrochloride | - 595. 1-Ethyl N4-sulfanilylcytosin
- [A short-acting, broad-spectrum sulfonamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic property. Sulfacytine competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death. ( NCI )] (UMLS (NCI) C0262960) =Organic Chemical; Antibiotic =Sulfanilamides;
[AM650] SULFONAMIDE/RELATED ANTIMICROBIALS =SULFACYTINE 250 MG |
- 546. 1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose, hydrochloride
- [The hydrochloride salt of an antimetabolite analog of the nucleoside pyrimidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. ( NCI )] (UMLS (NCI) C0771488) 2'Deoxy-2',2'-Difluorocytidine, Hydrochloride;
Difluorodeoxycytidine Hydrochloride;
Gemcitabine Hydrochloride;
GEMCITABINE HYDROCHLORIDE PREPARATION =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
=1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose;
=GEMCITABINE HYDROCHLORIDE 1 GM;
GEMCITABINE HYDROCHLORIDE 200 MG | - 596. 1-Ethyl-1-nitrosourea
- [A nitrosourea with potential antineoplastic activity. Used experimentally as a mutagen and carcinogen, ethylnitrosourea alkylates DNA and proteins, thereby damaging DNA and inducing point mutations. (NCI04) ( NCI )] (UMLS (NCI) C0015111) =Organic Chemical; Hazardous or Poisonous Substance ;
|
- 547. 1-(3'-Trifluoromethyl-4'-nitrophenyl)-4,4-dimethylimidazoline-3,5-dione
- [A drug that blocks the effects of male hormones in the body. It belongs to the family of drugs called antiandrogens. ( NCI )] (UMLS (NCI) C0068771) =Organic Chemical; Pharmacologic Substance =[AN000] ANTINEOPLASTICS;
imidazole;
[HS900] HORMONES/SYNTHETICS/MODIFIERS, OTHER;
=NILUTAMIDE 150 MG;
| - 597. 1-ethyl-2-[3-ethyl-5-(3-methylbenzothiazolin-2-yliden)-4-oxothiazolidin-2-ylidenemethyl] pyridinium chloride
- [A synthetic heterocyclic pyridinium compound. MKT-077 is a water soluble lipophilic cationic molecule and an analog of rhodacyanine dye, which partitions into tumor cell mitochondria where it is thought to act as a metabolic poison, leading to G1 arrest and apoptosis. This agent also shows selective cytotoxicity to cancer cells mediated by its binding to the hsp70 family protein mot-2 and reactivation of tumor suppressor p53 function. ( NCI )] (UMLS (NCI) C0386286) =Organic Chemical; Pharmacologic Substance ;
|
- 548. 1-(3,4-Dimethoxybenzoyl)-4-(1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)piperazine
- [A cardiotonic quinolinone derivative, that suppresses cell proliferation and induces apoptosis by inducing the expression of p21, an inhibitor of cyclin dependent kinase activity in p53-mediated cell cycle arrest. (NCI) ( NCI )] (UMLS (NCI) C0148345) =Organic Chemical; Pharmacologic Substance ;
| - 598. 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-2-pyrrolidinone Monohydrochloride, Monohydrate
- [A peripheral and central respiratory stimulant with a brief duration of action. Doxapram hydrochloride stimulates respiration by an action on chemoreceptors in the carotid arteries and, at increased dosage, stimulates central respiratory centers in the medulla as well as other parts of the brain and spinal cord. This results in an increased tidal volume and a slightly increased respiratory rate. Doxapram hydrochloride may also improve cardiac output probably due to an increased release of catecholamines. This respiratory stimulant is used in postanesthesia respiratory depression. ( NCI )] (UMLS (NCI) C0282152) =Organic Chemical; Pharmacologic Substance ;
=DOXAPRAM;
=DOXAPRAM HYDROCHLORIDE 20 MG/ML;
|
- 549. 1-(3,4-Dimethoxyphenyl)-2-propene
- [A yellowish, oily, naturally occurring liquid with a clove-like aroma and is present in many essential oils. Methyleugenol is used as a flavoring agent, as a fragrance and as an anesthetic in rodents. Methyleugenol is mutagenic in animals and is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in animals. (NCI05) ( NCI )] (UMLS (NCI) C0066372) =Organic Chemical; Pharmacologic Substance ;
| - 599. 1-fluoro-2,4-dinitrobenzene
- [Irritants and reagents for labeling terminal amino acid groups. ( MSH )] (UMLS (NCI) C0012463) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid ;
|
- 550. 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine
- (UMLS (NCI) C0533112) =Organic Chemical; Pharmacologic Substance
| - 600. 1-Fluoroethene
- [A synthetic, colorless gas that is insoluble in water and soluble in organic solvents. It is used primarily in the production of polyvinyl fluoride and other fluoropolymers. Vinyl fluoride is extremely flammable and emits highly toxic hydrogen fluoride gas when burned. Vinyl fluoride metabolites form covalent DNA adducts that attribute to inhibition of DNA replication and to mutagenicity consequences. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0078265) =Organic Chemical; Hazardous or Poisonous Substance ;
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