UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM - Terms starting with ‘Z’

selected terms: 3

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1. MIZ-1 Protein: [Encoded by human oncogene ZNF151 Gene (Kruppel Family) and highly expressed in brain and muscle, 803-amino acid 88 kD Zinc Finger Protein 151, similar to Z13 (mouse), contains an N-terminal BTB/POZ domain and thirteen C2H2 zinc finger domains connected by conserved H/C links. Predominantly cytoplasmic, ZNF151 may arrest growth (S/M) by activation of growth inhibitory genes. Associated with microtubules, ZNF151 may activate gene transcription in response to cytoskeletal changes. ZNF151 can transactivate cyclin D1 (CCND1,) alpha-2 integrin, and LDLR. ZNF151 interacts specifically with the HLH domain of MYC and NMYC. MYC interaction inhibits ZNF151 transactivation, induces ZNF151 nuclear sequestration, and overcomes ZNF151-induced growth arrest. (OMIM, Swiss-Prot, and NCI) ( NCI )] (UMLS (NCI) C0665379) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;